Fabio Fognini defeated Rafael Nadal twice on clay in 2015.
Novak Djokovic lost serve five times in a 6-3, 4-6, 6-2 defeat by Russia's 10th seed Daniil Medvedev.
Ashleigh Barty leads Australia's hopes of reaching a first Fed Cup final since 1993 when they face 2017 runners up Belarus in Brisbane.
Rafael Nadal showed no sign of the knee problems and dominated the match completely.
Novak Djokovic was severely tested before securing a 6-3, 4-6, 6-4 win over Philipp Kohlschreiber.
Rafael Nadal, a keen golfer himself, expressed nothing but admiration for Tiger Woods, who has fought through at least as many physical challenges as he has himself.
For Rafael Nadal, it's all about his troublesome left knee while for Novak Djokovic, the major goal will be to emerge from a minor slump.
Roger Federer beat John Isner in straight sets in the Miami Open final to claim his 101st title.
Ashleigh Barty will rise from 11th to number nine in the world rankings and become the first Australian woman since Sam Stosur in June 2013 to crack the top 10.
Roger Federer will play John Isner, who lifted the 2018 title, in Sunday's Miami Open final after the American beat Felix Auger-Aliassime in straight-sets.
Roger Federer booked a Miami Open semi-final against Denis Shapovalov with a ruthless 6-0, 6-4 destruction of Kevin Anderson.
Roger Federer rolled back the years with a dominant display to serve notice of his intent to land his 101st career title in Sunday's final.
Roberto Bautista Agut superbly recovered from a first set destruction to win 1-6, 7-5, 6-3.
Roger Federer produced an excellent all-round performance despite being tested by the world number 103 Filip Krajinovic.
Miami Open: Hsieh Su-Wei battled back from being a set down to beat Naomi Osaka 4-6, 7-6 (7/4), 6-3.
Roger Federer booked a round of 32 match with Serbian Filip Krajinovic who surprised three-time Grand Slam winner Stan Wawrinka.
Nocak Djokovic progresses to the Miami Open third round with a ruthless 7-6 (7/2), 6-2 destruction of Australian Bernard Tomic.