Maurizio Sarri's assistant Gianfranco Zola claimed after the match that the decision to send his compatriot to the stands was unfair.
Christian Eriksen ended Brighton's stubborn resistance with a sensational long-range drive that lifted Tottenham three points clear of fourth-placed Chelsea and four ahead of Arsenal in fifth.
James Milner said he would be delighted if Manchester United did Liverpool a favour in the Manchester derby at Old Trafford.
It was a missed opportunity after defeats for Tottenham, Arsenal and United at the weekend and Chelsea were booed off at full-time.
Mohamed Salah was grappled inside the area but the theatric nature of his fall saw Neil Warnock compare to British Olympic bronze medallist diver Tom Daley.
Karim Benzema has been one of the few bright sparks in an otherwise dreary campaign for Real Madrid and his hat-trick at the Santiago Bernabeu took his tally to 30 goals for the season.
Qatar-backed PSG are now 16 points ahead of Lille who have five games to play.
Liverpool move two points ahead of Manchester City, who still have a game in hand, at the top.
Barcelona are closing in on their eighth La Liga title in 11 years after Clement Lenglet and Jordi Alba both scored in a 2-1 win over Real Sociedad.
Juventus dominated the league, bolstered by Cristiano Ronaldo who they purchased for 100 million euros (USD 112 million) last summer.
Pep Guardiola's men edge one point ahead of Liverpool once more with four games of a titanic title race left for both sides.
After a spectacular start for Ole Gunnar Solskjaer as caretaker manager of the club, Manchester United have since suffered a precipitous drop in form.
Manchester City will face Watford in the FA Cup final at the London venue on May 18.
Alexandre Lacazette's stunning 36th-minute free-kick put Arsenal through to a Europa League final four meeting with Spanish side Valencia.
Chelsea will face Eintracht Frankfurt for a place in the Europa League final after the German side beat Benfica 2-0 on Thursday to go through on away goals.
Manchester City's quadruple bid was shattered by a "cruel" Champions League quarter-final exit on Wednesday.
Liverpool crushed FC Porto 4-1 in Portugal on Wednesday to win their Champions League quarter-final tie 6-1 on aggregate.