Champions League: Marcos Llorente's extra-time double helped Atletico Madrid grab a 3-2 win on the night over Liverpool and 4-2 victory on aggregate.
Sadio Mane scored the winner with nine minutes left as Liverpool moved 22 points clear of second placed Manchester City.
A 24th victory in 25 league matches this season and ninth clean sheet in 10 games underlined how Liverpool have turned the title race into a procession.
Liverpool have turned the title race into a procession and the runaway leaders saw off struggling West Ham to make it a remarkable 23 victories from 24 league games this season.
Goals from Virgil Van Dijk and Mohamed Salah gave Liverpool a 2-0 win over rival Manchester United.
Liverpool haven't lost a game in the league this season and are on top of the points table with 58 points from 20 games, while Tottenham Hotspur are sixth with 30 points from 21 matches.
Liverpool's 19th win in 20 league games this season completed an incredible 12 months for a team at the peak of their powers.
Roberto Firmino scored twice from Trent Alexander-Arnold crosses either side of James Milner's penalty before the brilliant Alexander-Arnold rounded off the scoring himself.
Liverpool safely negotiated Tuesday's trip to Salzburg to take their place in the last 16 of this season's UEFA Champions League.
Premier League: Liverpool took a huge step towards a first Premier League title in 30 years by beating defending champions Manchester City 3-1.
Premier League 2019, Liverpool vs Man City Highlights: Fabinho, Mohamed Salah and Sadio Mane scored for Liverpool, while Bernardo Silva scored Man City's only goal.
Liverpool, who top the Premier League table, host defending champions Manchester City at Anfield on Sunday.
Alex Oxlade-Chamberlain scored twice in Liverpool's 4-1 Champions League win over Genk in Belgium on Wednesday.
Liverpool vs Leicester: Victory came at a cost for Liverpool with Mohamed Salah limping off injured late on with an injury caused by Hamza Choudhury's lunge.
Champions League: Mohamed Salah's brace helped Liverpool clinch crucial points against Red Bull Salzburg.
Roberto Firmino provided a stunning assist for Mohamed Salah's goal and was named man-of-the-match despite only coming on eight minutes before half-time.
Mohamed Salah brushed aside his supposed falling out with Liverpool teammate Sadio Mane by posting a brilliant video.
Liverpool captain Jordan Henderson insists Sadio Mane's touchline tirade at Burnley showed his side's desire to win the Premier League.