Rafael Nadal is chasing a 12th French Open title while 2009 champion Roger Federer is playing in the tournament for the first time since 2015.
Novak Djokovic and Rafael Nadal will now attempt to claim a 34th Masters title in Rome this week.
Stefanos Tsitsipas' surprise victory over Rafael Nadal means he reaches his fourth ATP final of the season.
If Rafael Nadal overcomes the talented Stefanos Tsitsipas later on Saturday, it will be the Spaniard and Djokovic in Sunday's final.
Simona Halep awaits either Dutch seventh seed Kiki Bertens, a finalist in Madrid last year, or 2017 US Open champion Sloane Stephens in the final.
Roger Federer admitted he struggled to get past the talented Gael Monfils.
Roger Federer needed just 52 minutes to brush Richard Gasquet aside in the second round.
Roger Federer last tested his ability on European dirt at the Rome Masters in 2016, before opting to concentrate on the world's hard surfaces and grass courts.
Novak Djokovic, winner of the last three Grand Slam tournaments, is now over 3,000 points clear of rival Rafael Nadal.
Novak Djokovic lost serve five times in a 6-3, 4-6, 6-2 defeat by Russia's 10th seed Daniil Medvedev.
Novak Djokovic was severely tested before securing a 6-3, 4-6, 6-4 win over Philipp Kohlschreiber.
For Rafael Nadal, it's all about his troublesome left knee while for Novak Djokovic, the major goal will be to emerge from a minor slump.
Roberto Bautista Agut superbly recovered from a first set destruction to win 1-6, 7-5, 6-3.
Nocak Djokovic progresses to the Miami Open third round with a ruthless 7-6 (7/2), 6-2 destruction of Australian Bernard Tomic.
Novak Djokovic maintains he would welcome the input of Roger Federer and Rafael Nadal.
Novak Djokovic was playing his first tournament since lifting a record seventh title in Melbourne, taking his tally of Grand Slam victories to 15.
Alexander Zverev crashed out of the ATP Indian Wells Masters after losing to Jan-Lennard Struff, ranked 55th in the world.
Novak Djokovic is making his first start since winning his third Grand Slam title on the trot at the Australian Open in January.