Between mid-January 2015 and June 2016, Djokovic won 17 of his 22 finals played in 24 tournaments.
Roger Federer won his eighth Wimbledon crown without dropping a set.
Novak Djokovic was trailing 7-6, 2-0 and felt he had no option but to call it quits as the pain, from an injury that has troubled him for more than a year, began to increase.
Czech world number 15 Berdych, the 2010 Wimbledon runner-up, goes on to face Roger Federer or Milos Raonic for a place in Sunday's final.
Novak Djokovic will face the Czech Republic's Tomas Berdych on Wednesday for a semi-final spot, boasting a 25-2 career record over the 2010 Wimbledon runner-up.
Three-time champion Novak Djokovic reached the fourth round for the 10th time, Angelique Kerber saved her No 1 rank with a win over Shelby Rogers.
Roger Federer hit his 10,000th career ace in the eighth game of the first set.
Novak Djokovic clinched his first title since January with a 6-3, 6-4 victory over Gael Monfils.
Murray will enter the tournament desperately trying to shake off a hip injury which played a part in his Queen's Club title defence coming to an abrupt end in the first round last week.
The former coach of Novak Djokovic is declared bankrupt by a court in London after failing to pay substantial long-standing debt.
Simona Halep produced an incredible escape act to reach the French Open semi-finals on Wednesday.
Dominic Thiem demolished defending champion Novak Djokovic 7-6, (7/5), 6-3, 6-0.
Swiss Bacsinszky reached the women's semis for the second time at Roland Garros, to meet Latvian teen Ostapenko.
All singles rubbers will be played on a best-of-three set basis instead of the traditional best-of-five.
Nine-time champion Rafael Nadal lost just one game in a ruthless display to reach the French Open last 16 on Thursday, but title-holder Novak Djokovic needed five sets to survive.
Defending champion Djokovic battered Portugal's Joao Sousa 6-1, 6-4, 6-3 to make it four wins in as many meetings with the world number 59.
Nadal began his pursuit of a record 10th French Open title with an easy win over Benoit Paire as Djokovic brushed aside Marcel Granollers to reach the second round.
The 30-year-old Spaniard is the overwhelming favourite to win the title at Roland Garros.
