Jack Grealish ensured Manchester City ended their four-game winless run as the Premier League champions survived a scare from Luton in their 2-1 victory
Bruno Fernandes has apologised for Manchester United's embarrassing defeat against Bournemouth as the Portugal star admitted his side did not have enough effort or quality.
Arsenal's second league defeat of the season leaves Mikel Arteta's men one point behind Liverpool, who went top with a controversial 2-1 win at Crystal Palace earlier on Saturday.
Manchester United's shambolic season took another turn for the worse in a 3-0 home defeat to Bournemouth as Liverpool went top of the Premier League on Saturday
Arsenal's grip on the Premier League's top spot will be under threat from their old boss Unai Emery when the leaders travel to surging Aston Villa on Saturday.
Newcastle were made to pay for two uncharacteristic errors by England international Kieran Trippier as fatigue hit the injury-ravaged Magpies in the closing stages.
Spurs came into the match in buoyant mood after an enthralling 3-3 weekend draw against champions Manchester City and they started in style at the Tottenham Hotspur Stadium.
United, who host Chelsea on Wednesday, are also in grave danger of being eliminated from the Champions League when they face Bayern Munich in their last group match next week.
The wild celebrations from Arteta and his players underlined the significance of a gritty escape that will fuel the belief Arsenal can finally win their first title since 2004.
Pep Guardiola's champions led 2-1 at the break thanks to a Phil Foden goal after Spurs captain Son Heung-min had scored at both ends, but Giovani Lo Celso's superb strike made it 2-2.
Liverpool trail City by a solitary point in the Premier League table and head into this fixture hoping to prove they are once again genuine title contenders.
A share of the spoils at Stamford Bridge leaves City one point ahead of Liverpool, who beat Brentford 3-0, and Arsenal at the top of the table. Palmer came back to haunt his former club as City three times let the lead slip against the Blues.