Roberto Firmino's late winner opened up a 16-point lead for Liverpool at the top of the Premier League with a 2-1 victory at Wolves.
Ole Gunnar Solskjaer's side suffered a third defeat in their last four Premier League games to put the Manchester United boss' job security back under the microscope.
Arsenal slowed Chelsea's charge for a Champions League place as Manchester City kept up their distant pursuit of Liverpool with victory at Sheffield United.
A slump in form from Frank Lampard's men has left the door open for Manchester United, Tottenham and Arsenal to secure a much-needed return to Champions League.
Goals from Virgil Van Dijk and Mohamed Salah gave Liverpool a 2-0 win over rival Manchester United.
Manchester United manager Ole Gunnar Solskjaer believes Liverpool have to demonstrate the ability to keep winning year after year before they deserve to be ranked alongside Manchester United's best outfits.
Pep Guardiola's 49th birthday celebrations went flat as Fernandinho's late own goal forced Manchester City to settle for a 2-2 draw against Crystal Palace.
Fernandinho's late own goal forced Manchester City to settle for a 2-2 draw against Crystal Palace, while Tottenham were held to a goalless draw by Watford.
Manchester United will travel to Anfield as they take on table-toppers Liverpool on Sunday.
Ashley Young spent the past eight-and-a-half seasons at Old Trafford since arriving from Aston Villa in 2011 for around 20 million pounds ($26 million).
Pep Guardiola admitted that he is now interested only in securing a top-four finish and chasing honours in three cup competitions rather than events at Anfield involving Liverpool.
Manchester City thrashed Aston Villa 6-1 to move ahead of Leicester into second on the Premier League points table.
Liverpool have earned 61 points from a possible 63 in 21 games to streak 16 points clear at the top and with a game in hand over second-placed Leicester.
Chelsea and Manchester United secured comfortable wins in the race for the Premier League top four.
Marcus Rashford scored twice on his 200th Manchester United appearance as Ole Gunnar Solskjaer's team beat Norwich 4-0.
Manchester City will look to leapfrog Leicester City and keep the pressure on league leaders Liverpool.
Pierre-Emerick Aubameyang's opening goal was cancelled out by a Jordan Ayew strike in the second half.
VAR is in the spotlight again after West Ham were condemned to defeat following a last-minute contentious handball decision at Bramall Lane.