Sandeep Lamichhane was the wrecker-in-chief, taking six for 16 as the American side were finished off in 12 overs in the World Cup league two match in Kathmandu.
Kushal Malla scored 50 off 51 balls on his ODI debut in a World Cup League 2 match against the US near Kathmandu on Saturday aged 15 years and 340 days.
Nepal's Anjali Chand took six wickets without conceding any runs against Maldives to help her team register an emphatic win by 10 wickets.
Zimbabwe will now be able to participate in the ICC Men's U-19 World Cup in January 2020 and the ICC Super League later in 2020.
Nepal's Paras Khadka became the only captain to score a century while chasing in a T20I match.
The ICC World Cup 2019 begins in England and Wales on May 30.
China have struggled big-time in ICC's latest regional qualifier for the next World T20 in 2020 and this was yet another dismal performance.
Chasing 217 to win, the Dutch were comfortably placed at 114-2 at one stage, before losing their next seven wickets for 71 runs.
Rohit Kumar Paudel, at 15 years and 335 days, is the fourth-youngest player to make his ODI debut.
Chasing a modest 190 to win, Nepal, playing their first 50-over game since securing ODI status earlier this year, were bowled out for 134 with more than eight overs to spare.
The four teams have been added to the 12 Test-playing nations already existing on the list.
Sandeep Lamichhane was spotted by then Nepal coach Pubudu Dassanayake in 2014 and represented Nepal in the ICC Under-19 Cricket World Cup 2016.
Sandeep Lamichhane became the first Nepalese player to get an Indian Premier League (IPL) contract when he was picked by Delhi Daredevils for his base price of Rs 20 lakh at the Player's Auction in January.
Nepal's bowlers laid the platform for the comprehensive win, with Sandeep Lamichhane and Dipendra Airee taking four wickets apiece.
The 17-year-old leg-spinner Lamichhane, who will be the first-ever Nepalese IPL player in April with the Delhi Daredevils, had earlier taken 2-40 as Canada posted 194-8 from their 50 overs.
Lamichhane shot to fame during the U-19 World Cup in 2016, when he picked up 14 wickets to become the second highest wicket-taker at the tournament. Lamichhane even registered a hat-trick against Ireland during his spell of 5/27.
Dipendra Singh Airee starred with both bat and ball as minnows Nepal stunned defending champions India, coached by Rahul Dravid, by 19 runs in their Under-19 Asia Cup match in Kuala Lumpur on Sunday.
Nepal captain Raju Rijal is facing a controversy regarding his age, with a former Ranji Trophy player Kaustubh Pawar alleging that he is a man called Raju Sharma