Pablo Carreno Busta beat Argentine 29th seed Diego Schartzman 6-4, 6-4, 6-2.
The field of newbies, who compete on Sunday for the first four spots in the US Open quarterfinals, is as eclectic as they come.
Cilic won 83 percent of first serve points, while Querrey took 85 percent in the first set.
Wimbledon 2017 highlights: Seventh seed Marin Cilic will play 18-time Grand Slam champion Roger Federer in the men's singles final at Wimbledon after the Swiss beat Tomas Berdych in straight sets on Friday. Cilic quelled Sam Querrey's challenge in four sets to reach his first Wimbledon final.
World No. 1 Andy Murray has a history of standing up for equality in professional tennis.
Sam Querrey sent defending champion Andy Murray crashing out of Wimbledon on Wednesday, reaching his first Grand Slam semi-final at the 42nd attempt.
Sania Mirza and Barbora Strycova could next face the team of Martina Hingis and Chan Yung-jan in the Indian Wells women's doubles quarterfinals.
Rohan Bopanna is all set to clash with Novak Djokovic in the ATP Indian Wells Masters event while Leander Paes will be seen playing with Juan Martin Potro and the pair will be up against Gilles Muller and American Sam Querry.
Sam Querrey fired 19 aces en route to his first career victory over Rafael Nadal in five meetings.
Milos Raonic is the first Canadian to make the last four at Wimbledon more than once. He will face the either Roger Federer or Marin Cilic on Friday for a place in the final.