Pablo Carreno Busta beat Argentine 29th seed Diego Schartzman 6-4, 6-4, 6-2.
The field of newbies, who compete on Sunday for the first four spots in the US Open quarterfinals, is as eclectic as they come.
Cilic won 83 percent of first serve points, while Querrey took 85 percent in the first set.
Wimbledon 2017 highlights: Seventh seed Marin Cilic will play 18-time Grand Slam champion Roger Federer in the men's singles final at Wimbledon after the Swiss beat Tomas Berdych in straight sets on Friday. Cilic quelled Sam Querrey's challenge in four sets to reach his first Wimbledon final.
World No. 1 Andy Murray has a history of standing up for equality in professional tennis.
Sam Querrey sent defending champion Andy Murray crashing out of Wimbledon on Wednesday, reaching his first Grand Slam semi-final at the 42nd attempt.
Sania Mirza and Barbora Strycova could next face the team of Martina Hingis and Chan Yung-jan in the Indian Wells women's doubles quarterfinals.
Rohan Bopanna is all set to clash with Novak Djokovic in the ATP Indian Wells Masters event while Leander Paes will be seen playing with Juan Martin Potro and the pair will be up against Gilles Muller and American Sam Querry.
Sam Querrey fired 19 aces en route to his first career victory over Rafael Nadal in five meetings.
Milos Raonic is the first Canadian to make the last four at Wimbledon more than once. He will face the either Roger Federer or Marin Cilic on Friday for a place in the final.
Roger Federer is on the cusp of reaching his 11th Wimbledon semi-final and become the most successful Grand Slam match winner
Roger Federer advanced to the quarter-finals of the Wimbledon by seeing off Steve Johnson of the United States 6-2, 6-3, 7-5 in the fourth round on Centre Court
Novak Djokovic, after losing to Sam Querrey in the Wimbledon third round, said he would focus on his four-in-a-row Grand Slam wins than on failure
Andy Murray beat Australia's John Millman 6-3, 7-5, 6-2 to enter Wimbledon fourth round.
Novak Djokovic, who was aiming to win the calendar slam, crashed out of Wimbledon in the third round after suffering a shock loss to American Sam Querrey
Sam Querrey, who is ranked number 41 in the world, pulled off a remarkable upset by defeating top seed Novak Djokovic in the third round of Wimbledon 2016
Novak Djokovic, top seed and defending champion, was sent crashing out of Wimbledon by United States' Sam Querrey in the third round
Novak Djokovic lost the first two sets against Sam Querrey before persistent rain then saw the match postponed until Saturday. On the other hand, Roger Federer advanced to fourth round with a thumping win over Daniel Evans