Real Madrid slipped to a 2-1 defeat at Espanyol on Sunday as Carlo Ancelotti's side followed up a shock Champions League reverse with their first Liga defeat of the season.
La Liga: Thomas Lemar scored a late winner as Atletico Madrid edged past Espanyol on Sunday.
Barcelona and Espanyol were both reduced to 10 men in the second half before Luis Suarez netted the winner for the home side at the Camp Nou.
Real Madrid registered a narrow 1-0 win over bottom club Espanyol to open a two-point lead over Barcelona at the top of La Liga.
Mauricio Potchettino recalled how he and Jose Mourinho had forged a close relationship during their days as rivals in Spain's La Liga.
On Friday the Spanish government announced that over 4,800 people have died in the country as a result of coronavirus after 769 people died in the previous 24 hours, a record one-day figure for fatalities in Spain.
Karim Benzema scored one and set up another in Real Madrid's 2-0 win at the Santiago Bernabeu
Barcelona continued their march towards the La Liga title on Saturday with a 2-0 win over Espanyol.
Gareth Bale had been out since January 3 with a calf strain but made an instant impact off the bench for Real Madrid.
Lionel Messi made sure that Ernesto Valverde's team kept their place at the top of the pile with a mesmerising display.
Cristiano Ronaldo was rested and the supporting cast failed to show up as Real Madrid endured a shock 1-0 defeat away to Espanyol on Tuesday.
Barcelona and Real Madrid remain locked together on 81 points at the top of La Liga after seeing off Espanyol and Valencia respectively on Saturday.
Gareth Bale, who came on as a substitute on Saturday after three months on the sidelines, scored seven minutes from time as Real Madrid defeated Espanyol 2-0
After three matches, Real Madrid lead La Liga standings with nine points and face Espanyol next, who are 15th with two points
Barcelona are only one win away from the La Liga title as Atletico Madrid went out of the race after losing to Levante. Real Madrid still have a chance if they win their final league game and Barcelona lose.
Cristiano Ronaldo's 29th hat-trick in La Liga helped Real Madrid CF crush Espanyol 6-0.
Lionel Messi was once again FC Barcelona's inspiration as he brilliantly picked out Munir El Haddadi to open the scoring before the youngster tapped home his second against Espanyol. Barcelona won 2-0 as they advanced to the Copa del Rey quarter-finals 6-1 on aggregate.
FC Barcelona issued a statement saying they would appeal the ruling, denying Luis Suarez insulted Espanyol players in a heated Copa de Rey clash between the two teams.