Manchester United, unbeaten in eight games in the tournament, finished in third place and Tottenham came fourth, ensuring the Premier League clubs both avoided the Europa League play-off round.
A stoppage time strike from Adam Hlozek snatched Hoffenheim a 2-2 home draw against Eintracht Frankfurt on Sunday, cancelling out a brace from Hugo Ekitike
The result means Borussai Dortmund, who played in the Champions League final in June, have lost their past three and have just one victory in their last six games.
Goals from Benjamin Sesko and Lois Openda took Leipzig to a 2-1 home win over Eintracht Frankfurt on Sunday, days out from their trip to league leaders Bayern Munich.
Toiling quietly behind leaders Bayern Munich and surprise package Eintracht Frankfurt, Bayer Leverkusen have returned to the form which took them to a league-cup double last season.
Omar Marmoush scored a goal in each half as Eintracht Frankfurt won 4-0 at Heidenheim on Sunday, cutting the gap on Bayern Munich to four points.
RB Leipzig lost more ground on Bundesliga leaders Bayern Munich with a 4-3 defeat at lowly Hoffenheim on Saturday
Eintracht Frankfurt striker Omar Marmoush continued his blistering run of form in the Bundesliga on Sunday with an assist and a goal in his side's 3-2 win away to Stuttgart
Victor Boniface's 72nd-minute goal was the difference as Bayer Leverkusen beat Eintracht Frankfurt 2-1 at home, while RB Leipzig won 2-0 at Mainz to go top of the table.
Egyptian forward Omar Marmoush scored twice, including an injury-time equaliser to secure a 3-3 draw for Eintracht Frankfurt and deny Bayern Munich a two-point cushion at the top of the Bundesliga
Manchester United will also notably play at home to 2022 Europa League runners-up Rangers and go to Portugal to play Porto, another of Jose Mourinho's old sides.
Eintracht Frankfurt came from a goal down to draw 1-1 at home in a feisty match with Werder Bremen on Saturday as both sides finished a man down.
Mario Goetze toasted the career of former mentor Jurgen Klopp, who announced Friday he would step down as Liverpool coach at season's end.
Leaders Bayer Leverkusen retain their three-point cushion and travel to third-place Stuttgart on Sunday on a weekend when six of the Bundesliga's top seven face each other.
Unbeaten Bayern sit three points behind Leverkusen with a game in hand, after last week's home match against Union Berlin was postponed due to heavy snowfall.
A late equaliser from Julian Brandt saw Borussia Dortmund rescue a point in a thrilling 3-3 draw with Eintracht Frankfurt in the Bundesliga
After featuring in four of the past five German Cup finals, Leipzig's second title in two years firmly establishes themselves alongside Borussia Dortmund as challengers to Bayern Munich's throne.
Three German football fans and five locals were arrested following clashes with police in Naples before and after Napoli's Champions League win over Eintracht Frankfurt