Juventus coach Massimiliano Allegri believes the Italian football champions will approach the return leg in London like a final.
Harry Kane's latest heroics also made it sweet revenge for Tottenham after they were beaten at Arsenal earlier this season.
Liverpool remain in third place, while Tottenham Hotspur are two points behind Jurgen Klopp's side in fifth.
The result moves Spurs to within two points of fourth-placed Liverpool, who have a game in hand, but it was not enough to lift Southampton out of the relegation zone.
Saturday's late kick-off saw England forward Kane score his 98th Premier League goal and surpass Teddy Sheringham's previous club record of 97.
Manchester United came from two goals down to rescue a dramatic 2-2 draw against Burnley thanks to Jesse Lingard's double.
Harry Kane's second goal took him to 55 for club and country in 2017 -- lifting him above Barcelona's Lionel Messi (54 goals).
Harry Kane took his goal tally in the Premier League to 36 for the calendar year, equalling the record set by Alan Shearer with Blackburn Rovers in 1995.
Though Harry Kane scored twice, Son was the star of the show, scoring one goal and having a say in four others
The result took already-qualified Tottenham Hotspur to 13 points and consigned Champions League holders Real Madrid to second place in the group with a game left.
A win will take Spurs or Madrid to the knockout stage.
Liverpool's defeat -- their first in 10 league games against Spurs -- also saw them become only the sixth team to have conceded over 1,000 goals since the Premier League was launched in 1992.
Raheem Sterling shone for Manchester City and Romelu Lukaku delivered for Manchester United as the Manchester clubs maintained a tight grip on the Premier League title race
Cristiano Ronaldo has now struck 12 times in his last six Champions League games.
Liverpool are on the brink of qualifying for the Champions League after Philippe Coutinho inspired a 4-0 rout of West Ham, while Tottenham said a fitting farewell to White Hart Lane with a 2-1 win against Manchester United on Sunday.
Dele Alli and Harry Kane kept Tottenham Hotspur in the Premier League title hunt as their side torpedoed Arsenal 2-0 while Chelsea maintained their advantage by winning 3-0 at Everton earlier in the day.
Vincent Janssen bagged a rare goal in second-half stoppage time as Tottenham Hotspur chalked up seven successive league wins for the first time since 1967.
A fifth goal in three games from Sergio Aguero, whose future at the club has been clouded by the recent impact of the now injured Gabriel Jesus, paved the way for City's seventh victory in eight unbeaten games.