In Hansi Flick's first season as manager, Barcelona are off to a flying start despite their continued financial difficulties.
Spanish champions Real Madrid earned a 3-0 win over Real Valladolid in La Liga on Sunday as Kylian Mbappe made his Santiago Bernabeu bow without finding the net.
Mbappe endured a difficult first La Liga game, away at Mallorca, as Real Madrid drew 1-1.
Valladolid were good value for their victory and climbed to 17th, moving provisionally three points clear of the relegation zone.
Atletico have little to play for in La Liga, sitting 13 points behind leaders Barcelona and 13 clear of fifth-placed Villarreal.
Karim Benzema buried his World Cup nightmare with two late goals as Real Madrid defeated Valladolid 2-0 on Friday to go top of Spain's La Liga.
Atletico Madrid won the 2020-21 La Liga title with a 2-1 win over Valladolid on Saturday
La Liga: Casemiro scored the winner as Real Madrid beat Real Valladolid 1-0 to go three points of league leaders Atletico Madrid.
Real Madrid missed the creativity of the injured Eden Hazard as only a fortuitous goal from substitute Vinicius Junior earned them a 1-0 victory over Real Valladolid in La Liga on Wednesday.
Antoine Griezmann picked up a "muscle injury in the quadriceps of his right leg" during Barcelona's 1-0 win over Real Valladolid in La Liga on Saturday.
Lionel Messi teed up Arturo Vidal's winner to become the first player to provide 20 assists in Spain's top flight since Xavi Hernandez in 2009.
If Barcelona fail to win away at Real Valladolid on Saturday, Real Madrid will clinch the La Liga title with two games to spare by beating Granada on Monday.
Atletico Madrid now have 52 points and a four-point edge over Getafe in their Champions League pursuit after winning for the first time behind closed doors at their Wanda Metropolitano stadium.
Antoine Griezmann surpassed Fernando Torres with his 130th goal for Atletico Madrid.
Victory puts Sevilla one point above Barcelona at the summit, two clear of Atletico and six ahead of Real Madrid, who are languishing in sixth.
Madrid reduced Barcelona's lead to eight points, meaning the Catalan side can't seal the domestic title by beating Real Betis on Sunday with four rounds still remaining.
Betis defender Antonio Amaya was sent off in injury time for a dangerous high kick, leaving both teams to finish with 10 men.
With the draw, Bilbao remained in 13th place and unbeaten in three games, while Valladolid stayed in 10th place.