Lionel Messi equalled Xavi Hernandez's record of 767 games for Barcelona against Huesca as the hosts ran out 4-1 winners.
Victory means Barcelona trail Atletico Madrid by eight points again after the leaders temporarily pulled 11 clear thanks to a hard-fought 2-1 win over Granada earlier on Saturday.
Antoine Griezmann led Barcelona back from the brink on Wednesday as they beat Granada 5-3 after extra-time to win a riveting cup tie and reach the Copa del Rey semi-finals.
Lionel Messi underlined his worth to Barcelona by scoring a sensational free-kick on Sunday as the Catalans registered a 2-1 win over Athletic Bilbao.
Antoine Griezmann took to Instagram to announce that he was ending his sponsorship contract with Chinese telecoms giant Huawei.
Barcelona qualified for the Champions League last 16 with two games to spare on Tuesday as Martin Braithwaite scored twice in a 4-0 win over Dynamo Kiev.
Atletico Madrid recorded their first league victory over Barcelona in 10 years, which put them three points ahead of Real Madrid, with a game in hand, and second in the table.
Lionel Messi can talk to other clubs in January and leave for free when his contract expires in June, with Manchester City expected to make a renewed attempt to lure the 33-year-old away from Camp Nou.
Lionel Messi came on at half-time to rescue Barcelona by scoring twice, including his first goal from open play this season, in a 5-2 victory over Real Betis on Saturday.
Barcelona failed to beat 10-man Alaves, a 1-1 draw leaving Ronald Koeman's side sitting 12th in La Liga table.
The draw brings an end to Ronald Koeman's perfect start as Barcelona manager but he might not be too displeased with a point, even if his team also had chances to snatch a winner.
Both Lionel Messi and Barcelona appear keen to put on a united front, at least for now, ahead of their return to La Liga later this month.
A mess of a season could still be saved by the Champions League but even the most optimistic of fans expect the worst against Bayern Munich, Barcelona's probable opponents in the quarter-finals.
Antoine Griezmann picked up a "muscle injury in the quadriceps of his right leg" during Barcelona's 1-0 win over Real Valladolid in La Liga on Saturday.
Barcelona and Espanyol were both reduced to 10 men in the second half before Luis Suarez netted the winner for the home side at the Camp Nou.
Antoine Griezmann returned to Barcelona's starting line-up at La Ceramica and repaid the faith with a stunning goal, teed up by Lionel Messi.
Antoine Griezmann is ready to return to the field for Barcelona after a forced break due to coronavirus.
Antoine Griezmann scored for Barcelona as they secured a 1-1 draw against Napoli in the first leg of their Champions League last-16 tie.