Goals in the second half from Rodrygo, Nacho Fernandez and Benzema in the 92nd minute mean Real Madrid extend their advantage to 15 points with six games left to play.
La Liga: After Sevilla's defeat, Ivan Rakitic stripped down to his underwear and gifted his full kit to Barcelona fans at Camp Nou.
LaLiga: Pedri scored a late winner as Barcelona edged past Sevilla in a 1-0 win.
Such is the optimism around Barcelona that Xavi was even asked on Wednesday if they could yet win the title, although for Real Madrid to spurn a 15-point advantage with 11 games to go, 12 in Barca's case, seems unthinkable.
Barcelona will not win La Liga, the Champions League or even the Copa del Rey and yet still they could make this season a success.
Ousmane Dembele turned the jeers to cheers at Camp Nou on Sunday by scoring a stunning goal and setting up two more in a 4-0 victory over Athletic Bilbao
Pierre Emerick-Aubameyang's hat-trick help Barcelona run riot at Mestalla to beat Valencia 4-1 and climb back into La Liga's top four on Sunday.
Anthony Martial said on Wednesday he is fit and ready to play immediately for Sevilla after joining on a six-month loan deal from Manchester United.
Sevilla stayed in touch with Real Madrid at the top of La Liga on Sunday after Rafa Mir's goal sealed a 1-0 win at home to Getafe.
Ronald Araujo struck just before half-time to rescue a point for Barcelona at 10-man Sevilla on Tuesday, a result which benefits La Liga leaders Real Madrid.
La Liga: Barcelona are in sight of La Liga's top four again after 19-year-old Nico Gonzalez scored a late winner to seal a much-needed victory over Elche before Atletico Madrid were beaten by Sevilla.
La Liga: Barcelona suffered their first defeat under Xavi Hernandez on Saturday as a 1-0 loss at home to Real Betis inflicted another blow on their hopes of catching the league's top four.
Vinicius Junior scored a scintillating 87th-minute winner as Real Madrid came from behind to defeat Sevilla 2-1 and move four points clear at the top of La Liga on Sunday.
La Liga: Eden Hazard struck in the 94th minute to help Real Madrid to a 2-2 draw against Sevilla.
It means Spain's title race suddenly appears wide open, two months after Atletico Madrid sat 10 points clear of both Barcelona and Real Madrid, with a game in hand.
La Liga: Sevilla goalkeeper Yassine Bounou scored an accurate left-footed equaliser against Real Valladolid and helped his side stay in the title race.
Erling Braut Haaland scored twice as Borussia Dortmund held off a late Sevilla fightback to reach the Champions League quarter-finals with a 5-4 aggregate win after a frantic 2-2 second-leg draw on Tuesday.
Copa Del Rey Final: Barcelona will face either Athletic Bilbao or Levante, who are 1-1 in their semi-final, in the final on April 17 in Seville.