Barcelona successfully bounced back from Saturday's surprise La Liga loss away at Valencia by hammering Leganes 5-0 in the Copa del Rey.
Barcelona's defeat to Valencia raised early doubts about Quique Setien's appointment and gave Real Madrid the chance to move three points clear at the top.
Real Madrid climbed above Barcelona to top La Liga on Saturday as Casemiro scored twice in a gritty 2-1 win over Sevilla.
Barcelona are second in the La Liga table, two points behind Real Madrid, following their 4-0 win over Sevilla at Camp Nou.
La Liga: Real Madrid are now four points clear of Barcelona after five games played.
Alejandro Pozo delivered the late dagger in 10-man Sevilla's 2-1 friendly win over Liverpool in Boston Sunday
Liverpool face Spanish side Sevilla on Sunday at Boston's Fenway Park baseball stadium in the second game of their three-match US tour.
Jose Antonio Reyes won a European under-21 title with Spain in 2002 and went on to play 21 times for Spain between 2003 and 2006, scoring four goals.
Lionel Messi leads the La Liga scoring charts after notching his 25th goal in 23 league appearances this season.
Lionel Messi made sure that Ernesto Valverde's team kept their place at the top of the pile with a mesmerising display.
Victory for Barcelona took them back to the top of La Liga, in front of Sevilla and Atletico Madrid, who were each held to 1-1 draws.
Real Madrid move two points behind Barcelona and only three adrift of leaders Sevilla.
Victory puts Sevilla one point above Barcelona at the summit, two clear of Atletico and six ahead of Real Madrid, who are languishing in sixth.
Lionel Messi scored and then went off injured as Barcelona beat Sevilla 4-2 at Camp Nou, in a six-goal thriller.
After eight games in La Liga, Barcelona are second with 15 points while Real Madrid are fourth with 14 points.
Barcelona started the day at the top of the pile and then Atletico Madrid enjoyed a couple of hours at the summit after edging past Real Betis.
Arsenal defeated Ukraine's Vorskla Poltava 4-2 in the Europa League, while in-form Chelsea registered a 1-0 win away to PAOK in Greece.
The likes of Arsenal, Chelsea, AC Milan and Sevilla will be seen in action in the Europa League group stage, which gets underway on Thursday.