Bayer Leverkusen have only lost one domestic match since the start of last season in a remarkable run.
Argentine forward Julian Alvarez scored a 90th-minute goal to win the game for Atletico Madrid.
Florian Wirtz scored twice as Bundesliga champions Bayer Leverkusen beat Borussia Moenchengladbach 3-1 on Saturday
A second-half goal from Alex Grimaldo sent Bayer Leverkusen to a 1-0 home win over Mainz, closing the gap with league leaders Bayern Munich to one point.
A frantic first half saw the score at 3-1 after just 19 minutes played, with Patrik Schick bagging two.
The gap at the top of the Bundesliga table is down to four points between Bayern Munich and Bayer Leverkusen.
In 2024, football's uncertainty reached a height it hasn't scaled in many years.
Toiling quietly behind leaders Bayern Munich and surprise package Eintracht Frankfurt, Bayer Leverkusen have returned to the form which took them to a league-cup double last season.
Bayern Munich were dumped out of the German Cup by holders Bayer Leverkusen as Nathan Tella's second-half goal secured a 1-0 win for the Bundesliga champions on Tuesday.
Boniface is Leverkusen's highest scorer in the league, with six goals and an assist in 10 games.
Leipzig's 2-1 loss at Dortmund last week, their first in the league this season, has given Vincent Kompany's Bayern the chance to grow their lead at the top of the table.
Liverpool's return of 12 points means they are almost certainly already assured of a place in the knockout phase, but are closing in on sealing direct progression to the last 16 via a top-eight finish in the 36-team league.
Here are the live streaming and live telecast details of Liverpool vs Leverkusen, UEFA Champions League 2024-25 game -
Bayer Leverkusen coach Xabi Alonso said it was "too early" to write off his side's title defence despite dropping more points in Saturday's 2-2 draw at Werder Bremen.
Victor Boniface wrote on social media on Sunday "god is the greatest" and "god says my time hasn't come."
Victor Boniface's 72nd-minute goal was the difference as Bayer Leverkusen beat Eintracht Frankfurt 2-1 at home, while RB Leipzig won 2-0 at Mainz to go top of the table.
Eintracht Frankfurt and in-form forward Omar Marmoush visit wounded Bundesliga champions Bayer Leverkusen on Saturday battling the weight of history.
Bayer Leverkusen on Saturday suffered another early setback in their Bundesliga title defence as they let slip a two-goal lead to draw 2-2 with struggling Holstein Kiel.