Hayley Matthews led the way for West Indies in a comprehensive nine-wicket victory.
Mandhana is placed second in the ICC Women's ODI batting rankings, and third in the T20I rankings.
Uncapped batter Simran Shaikh expressed her desire to meet India stalwart Virat Kohli and outlined her goal to represent the Indian national team.
India Women extended their unbeaten run against the West Indies to nine consecutive T20I victories with a dominating 49-run win in the series opener.
Pakistan won the toss and opted to bat first at Bayuemas Oval but the move backfired them as they were restricted to 67/7 in 20 overs with Sonam Yadav returning with the figures of 4-6 in her four overs.
WPL 2025 Auction Highlights: Leg-spinner Simran Shaikh turned out ot be the costliest player sold at Women's Premier League 2025 mini-auction on Sunday.
Skipper Harmanpreet Kaur on Saturday backed the Indian women's team to regain confidence in home conditions during the three-match T20I series against the West Indies.
India have won each of their last eight T20Is against the West Indies in the shortest format since November 2019.
On Sunday, the third Women's Premier League (WPL) player auction will see five teams vying to fill 19 slots overall from the pool of 120 players and complete their squads for the 2025 season at the premises of ITC Gardenia in Bengaluru.
Harmanpreet Kaur will continue to lead the squad with Smriti Mandhana, who struck a century in the third and last ODI in Australia, will remain the vice-captain.
Smriti Mandhana scored her fourth ODI century of 2024 during India's defeat to Australia at the WACA.
Despite Smriti Mandhana's 105, India failed to chase down a target of 299.
A battered and bruised India will look to avoid a clean sweep and address some glaring issues ahead of next year's 50-over World Cup at home when they face Australia in the third and final women's ODI
Opener Georgia Voll (101) and Ellyse Perry (105) smashed commanding centuries as Australia secured a series-clinching 122-run win over India in the second women's ODI.
A desperate India will need their under-fire batters to step up in the second Women's ODI against Australia in Brisbane on Sunday.
Opting to bat, India collapsed to 100 all out in 34.2 overs with Australia pacer Megan Schutt returning an impressive five-wicket haul.
Shafali Verma, dropped from the India ODI squad, has the full backing of skipper Harmanpreet Kaur despite the youngster absent from the series against Australia.
For India, the experienced Smriti Mandhana will bear the responsibility of providing a solid start with the bat.