Sebastian Vettel insisted that he can bounce back and help Ferrari return to competitive form at the front of the field.
"Honestly I'm proud, definitely, but I'm super-grateful to this incredible team and all the people at Mercedes who have continued to push this year," said Lewis Hamilton.
Lewis Hamilton's success extended his points-scoring run to a record-equalling 33 races, levelling with his own record, and brought him his 50th victory from pole position.
Max Verstappen was third for Red Bull ahead of the two Ferraris of Charles Leclerc and Sebastian Vettel with Alex Albon taking sixth in the second Red Bull.
Brazilian Grand Prix: Sebastian Vettel and Charles Leclerc were forced to retire from the race after they had collided while fighting for fourth place on Sunday.
Max Verstappen registered a commanding victory for Red Bull in an astonishing and crash-hit Brazilian Grand Prix at Interlagos.
Brazilian GP: Max Verstappen produced a best lap in one minute and 7.508 seconds to outpace four-time champion Sebastian Vettel's Ferrari in a final flurry.
Lewis Hamilton, who retained his crown in Texas two weeks ago, said he was as keen as ever to win the final events in Brazil and Abu Dhabi, but added that Mercedes can take more risks.
Lewis Hamilton sealed his sixth world title, leaving him one adrift of Michael Schumacher on seven.
Valtteri Bottas, the only man who can delay Lewis Hamilton's celebrations, kept alive his own faint and unlikely statistical hopes.
Lewis Hamilton needs only to finish in the top eight at the United States Grand Prix to be champion even if his Mercedes team-mate Valtteri Bottas wins the race.
Max Verstappen hit back at his critics, including Lewis Hamilton and Sebastian Vettel, saying their post-race comments in Mexico proved that he was "in their heads".
Lewis Hamilton believes that when racing against Max Verstappen, there is a higher possibility of contact and an accident.
Japanese Grand Prix: Sebastian Vettel clocked a brilliant 1min 27.064sec, almost two-tenths of a second quicker then Charles Leclerc after qualifying was postponed from Saturday.
If Japanese Grand Prix qualifying is not possible on Sunday morning because of continuing bad weather, then the grid will be decided based on Friday's second free practice times.
Sebastian Vettel disobeyed team orders in Russia and Charles Leclerc seemed to have a further dig at his teammate before trying, cryptically, to wriggle out of it.
Ferrari have developed the fastest car but it is Mercedes and Lewis Hamilton who are heading for the titles again.
Lewis Hamilton claimed his first win in four races on Sunday when he rode his luck to end Ferrari's winning streak with a well-judged strategic victory.