Bayern Munich swept RB Leipzig aside 5-1 on Friday to extend their lead at the top of the Bundesliga on a sombre night in Germany
Harry Kane is set to return to the Bayern Munich group before the Bundesliga leaders host RB Leipzig on Friday.
Goals from Benjamin Sesko and Lois Openda took Leipzig to a 2-1 home win over Eintracht Frankfurt on Sunday, days out from their trip to league leaders Bayern Munich.
An 85th-minute goal from Ross Barkley took Aston Villa to a 3-2 win at RB Leipzig on Tuesday, sending the visitors third in the table and boosting their hopes of a top-eight finish
Inter Milan took another step towards direct qualification for the last 16 of the Champions League with Tuesday's 1-0 win over Leipzig which moved the Italians top of the table.
RB Leipzig lost more ground on Bundesliga leaders Bayern Munich with a 4-3 defeat at lowly Hoffenheim on Saturday
Leipzig's 2-1 loss at Dortmund last week, their first in the league this season, has given Vincent Kompany's Bayern the chance to grow their lead at the top of the table.
Arne Slot has won 11 of his first 12 games in charge in all competitions, the best start of any manager in Liverpool history.
RB Leipzig host Liverpool in the Champions League on Wednesday as Jurgen Klopp's recent past and not-too-distant future collide.
Victor Boniface's 72nd-minute goal was the difference as Bayer Leverkusen beat Eintracht Frankfurt 2-1 at home, while RB Leipzig won 2-0 at Mainz to go top of the table.
In October, Jurgen Klopp announced he would join energy drink company Red Bull, which owns clubs in Leipzig, Salzburg and New York, as their global head of football from January 2025.
Bundesliga champions Bayer Leverkusen suffered their first Bundesliga defeat since May 2023 as a 3-2 loss at home to RB Leipzig on Saturday snapped their 35-match unbeaten run in the top flight.
Bayern face Freiburg, who have won only once in 17 previous meetings.
Every team will play eight games against eight different opponents in the new format of Europe's elite club competition, with all 36 clubs now pooled together into one league rather than split into groups.
Andrej Kramaric scored in the final minute of regular time to snatch Hoffenheim a 1-1 draw at home to 10-man RB Leipzig in the Bundesliga on Friday.
Fourth-placed Leipzig sit two points clear of Dortmund in fifth, with only the top four clubs guaranteed Champions League football next season.
A goal and an assist from Xavi Simons and a Lois Openda brace helped RB Leipzig thump Cologne 5-1 away on Friday to leapfrog Borussia Dortmund into the top four.
Real Madrid scraped through into the Champions League quarter-finals with a 1-1 second-leg draw against RB Leipzig on Wednesday, progressing 2-1 on aggregate.