Leipzig's 2-1 loss at Dortmund last week, their first in the league this season, has given Vincent Kompany's Bayern the chance to grow their lead at the top of the table.
Arne Slot has won 11 of his first 12 games in charge in all competitions, the best start of any manager in Liverpool history.
RB Leipzig host Liverpool in the Champions League on Wednesday as Jurgen Klopp's recent past and not-too-distant future collide.
Victor Boniface's 72nd-minute goal was the difference as Bayer Leverkusen beat Eintracht Frankfurt 2-1 at home, while RB Leipzig won 2-0 at Mainz to go top of the table.
In October, Jurgen Klopp announced he would join energy drink company Red Bull, which owns clubs in Leipzig, Salzburg and New York, as their global head of football from January 2025.
Bundesliga champions Bayer Leverkusen suffered their first Bundesliga defeat since May 2023 as a 3-2 loss at home to RB Leipzig on Saturday snapped their 35-match unbeaten run in the top flight.
Bayern face Freiburg, who have won only once in 17 previous meetings.
Every team will play eight games against eight different opponents in the new format of Europe's elite club competition, with all 36 clubs now pooled together into one league rather than split into groups.
Andrej Kramaric scored in the final minute of regular time to snatch Hoffenheim a 1-1 draw at home to 10-man RB Leipzig in the Bundesliga on Friday.
Fourth-placed Leipzig sit two points clear of Dortmund in fifth, with only the top four clubs guaranteed Champions League football next season.
A goal and an assist from Xavi Simons and a Lois Openda brace helped RB Leipzig thump Cologne 5-1 away on Friday to leapfrog Borussia Dortmund into the top four.
Real Madrid scraped through into the Champions League quarter-finals with a 1-1 second-leg draw against RB Leipzig on Wednesday, progressing 2-1 on aggregate.
Harry Kane scored two goals in the second-half, including an injury time winner, to snatch Bayern Munich a 2-1 home win over RB Leipzig on Saturday
Struggling Bayern Munich's shock decision to part ways with coach Thomas Tuchel at the end of the season will be put to the test in Saturday's clash with RB Leipzig.
An incredible solo goal from Brahim Diaz secured Real Madrid a 1-0 win away at RB Leipzig in Tuesday's Champions League last 16 first leg.
Jude Bellingham is also likely to miss league clashes with Rayo Vallecano, Sevilla and Valencia.
Leverkusen coach Xabi Alonso jumped with joy, securing a valuable three points against a top-four rival, although second-placed Bayern Munich have played two games fewer.
Four points behind with a game in hand, Harry Kane's Bayern are hovering dangerously close to a Leverkusen side hoping to break through for a first ever league title.