Leicester pushed Tottenham boss Ange Postecoglou closer to the exit door with a 2-1 win that extended Spurs' dismal run
Leicester City have lost their last seven Premier League games under manager Ruud van Nistelrooy, leaving them 19th in the table.
An inquest into the 2018 helicopter crash that killed the owner of Leicester City Football Club opened on Monday.
Liverpool's comeback lifted them well clear of second-placed Chelsea, who were beaten 2-1 by Fulham on Thursday.
Christmas Premier League chart-toppers Liverpool are overwhelming favourites to see off struggling Leicester on Boxing Day (Thursday).
United's second successive loss after their League Cup exit at Tottenham on Thursday underlined Ruben Amorim's belief that their road back to the top will be long and arduous.
The Reds sit five points clear of second-placed Chelsea, who can close the gap with a win against Brentford at Stamford Bridge on Sunday.
Ruud van Nistelrooy savoured his first match in charge of Leicester with a 3-1 Premier League win over West Ham, while Crystal Palace edged Ipswich 1-0 on Tuesday.
Two of Van Nistelrooy's three wins in four games as United's caretaker manager came against Leicester in the League Cup and Premier League.
Two of Van Nistelrooy's three wins in four games as United's caretaker boss in the past month came against Leicester in the League Cup and Premier League.
Manchester United signed off Ruud van Nistelrooy's temporary stint in charge with a 3-0 win over Leicester on Sunday as Ipswich stunned Tottenham 2-1 for their first Premier League victory in 22 years.
Ruud van Nistelrooy enjoyed a winning start as interim Manchester United manager by beating Leicester 5-2 to reach the League Cup quarter-finals on Wednesday
Chris Wood struck twice in Nottingham Forest's 3-1 win at Leicester as the New Zealand striker condemned Foxes boss Steve Cooper to defeat against his former club
Manchester City's second successive draw in the league was especially frustrating as Arsenal moved level on points with them with a last-gasp 4-2 win against Leicester a few hours later.
Manchester City won an unprecedented fourth Premier League title on the trot, edging Arsenal out by two points, despite failing to beat the Gunners home and away
Leicester have won their appeal against a decision that an independent commission had jurisdiction to consider an alleged breach of the Premier League's profit and sustainability rules.
Arsenal's Premier League title challenge hit its first stumbling block in a 1-1 draw with Brighton after Declan Rice was sent-off on Saturday, while Aston Villa won 2-1 away at Leicester.
Leicester City's return to the top flight was sealed after Leeds' shock 4-0 capitulation at QPR on Friday.