Arsenal made sure Liverpool cannot secure the Premier League title on Sunday by cruising to a 4-0 victory at 10-man Ipswich, while Chelsea beat Fulham 2-1 to climb into the Champions League places.
Antoine Semenyo struck in the first minute as Bournemouth boosted their hopes of qualifying for continental competition with a 1-0 Premier League victory over fellow European hopefuls Fulham
Liverpool slumped to just their second Premier League defeat of the season as Fulham struck three times in 14 first-half minutes to boost their own European ambitions with a 3-2 win.
Nottingham Forest beat Manchester United 1-0 to close in on Champions League football next season as Bukayo Saka scored in Arsenal's 2-1 win over Fulham on his return from injury on Tuesday.
Chelsea badly missed the presence of the absent Cole Palmer due to injury as they meekly surrendered to a damaging defeat for their hopes of a top-four finish.
Manchester United's dismal season hit a new low as the FA Cup holders crashed out after a 4-3 penalty shoot-out defeat against Fulham in the fifth round on Sunday
Manchester City face Plymouth Argyle, who shocked Liverpool, whilst Manchester United take on Fulham.
Chelsea duly delivered with three first-half goals through Christopher Nkunku, Pedro Neto and Levi Colwill for just a third league win 11 games.
Leicester pushed Tottenham boss Ange Postecoglou closer to the exit door with a 2-1 win that extended Spurs' dismal run
Raul Jimenez scored two penalties as Fulham twice came from behind to draw 2-2 with relegation-threatened Ipswich at Craven Cottage on Sunday.
Fulham scored twice in the final 10 minutes to end Chelsea's 12-game unbeaten run in all competitions with a stunning 2-1 Premier League win at Stamford Bridge.
United's second successive loss after their League Cup exit at Tottenham on Thursday underlined Ruben Amorim's belief that their road back to the top will be long and arduous.
The Reds sit five points clear of second-placed Chelsea, who can close the gap with a win against Brentford at Stamford Bridge on Sunday.
Chelsea roared back from two goals down to beat Tottenham 4-3 on Sunday, moving just four points behind Premier League leaders Liverpool after Arsenal were held by Fulham.
Arsenal missed the chance to close to within four points of Premier League leaders Liverpool after being held to a 1-1 draw at Fulham on Sunday.
Harry Wilson struck twice in stoppage time to give Fulham a dramatic 2-1 victory over west London rivals Brentford on Monday.
Arne Slot has now won nine of his first 10 games since succeeding Jurgen Klopp as Liverpool manager.
Manchester United crashed to a last-gasp 2-1 defeat against Brighton and an Erling Haaland's hat-trick fired Premier League champions Manchester City to a 4-1 win against Ipswich on Saturday.