Leicester pushed Tottenham boss Ange Postecoglou closer to the exit door with a 2-1 win that extended Spurs' dismal run
Raul Jimenez scored two penalties as Fulham twice came from behind to draw 2-2 with relegation-threatened Ipswich at Craven Cottage on Sunday.
Fulham scored twice in the final 10 minutes to end Chelsea's 12-game unbeaten run in all competitions with a stunning 2-1 Premier League win at Stamford Bridge.
United's second successive loss after their League Cup exit at Tottenham on Thursday underlined Ruben Amorim's belief that their road back to the top will be long and arduous.
The Reds sit five points clear of second-placed Chelsea, who can close the gap with a win against Brentford at Stamford Bridge on Sunday.
Chelsea roared back from two goals down to beat Tottenham 4-3 on Sunday, moving just four points behind Premier League leaders Liverpool after Arsenal were held by Fulham.
Arsenal missed the chance to close to within four points of Premier League leaders Liverpool after being held to a 1-1 draw at Fulham on Sunday.
Harry Wilson struck twice in stoppage time to give Fulham a dramatic 2-1 victory over west London rivals Brentford on Monday.
Arne Slot has now won nine of his first 10 games since succeeding Jurgen Klopp as Liverpool manager.
Manchester United crashed to a last-gasp 2-1 defeat against Brighton and an Erling Haaland's hat-trick fired Premier League champions Manchester City to a 4-1 win against Ipswich on Saturday.
Zirkzee scored in the 87th minute after coming on as a substitute.
Manchester City closed in on a fourth consecutive Premier League title by thrashing Fulham 4-0 on Saturday, while Burnley were relegated from the top flight after a 2-1 defeat at Tottenham.
Manchester City closed in on a fourth consecutive Premier League title by thrashing Fulham 4-0 on Saturday, while Burnley were relegated from the top flight after a 2-1 defeat at Tottenham.
Pep Guardiola insists Manchester City will be prepared for whatever conditions come their way at Fulham on Saturday after training on long grass.
Liverpool got their Premier League title challenge back on track with a 3-1 win at Fulham on Sunday to move level on points with leaders Arsenal.
Tottenham missed the chance to move into the Premier League's top four after a 1-1 draw at West Ham, while Newcastle were also held 1-1 by Everton on Tuesday.
Tottenham wasted a chance to move into the Premier League's top four as they slumped to a shock 3-0 defeat at Fulham
Harry Maguire admitted "naive" Manchester United paid the price for being too attacking in the final minutes of their shock 2-1 defeat against Fulham on Saturday.