Hansi Flick has warned Barcelona that Newcastle pose a serious threat to their Champions League ambitions as a product of "the best league in the world".
Manchester City shrugged off 10 changes to their starting line-up to crush Newcastle 3-1 and reach the FA Cup quarter-finals on Saturday as Chelsea battled past 10-man Wrexham.
Real Madrid and Manchester City will face off in a Champions League knockout tie for the fifth season running.
Newcastle United completed their stroll into the Champions League last 16 with a 3-2 win over Qarabag on Tuesday to progress 9-3 on aggregate over the Azeri champions.
Nico O'Reilly scored both goals for Pep Guardiola's team and extended Manchester City's unbeaten run in the league to five.
Norway's Bodo/Glimt stunned Inter Milan in the Champions League on Wednesday, beating last season's runners-up 3-1 in the first leg of their knockout phase play-off tie.
Mansfield produced the only shock of note so far in the fourth round by coming from behind to win 2-1 at top tier Burnley on Saturday.
Liverpool advanced to the fifth round of the FA Cup by defeating Brighton & Hove Albion 3-0 at Anfield.
Benjamin Sesko salvaged a 1-1 draw for Manchester United at West Ham as Michael Carrick's perfect start came to an end on Tuesday.
Manchester City will face Arsenal in the League Cup final after ending Newcastle's reign as holders with a first-half blitz in their 3-1 victory.
Title-holders Paris Saint-Germain and Newcastle United will both go into the Champions League play-off round after playing out a 1-1 draw in their final match of the league phase on Wednesday.
Aston Villa closed to within four points of the Premier League summit with an impressive 2-0 win at Newcastle.
Liverpool eased to a 3-0 win in Marseille in the Champions League as Harry Kane's double earned Bayern Munich a 2-0 victory against Union Saint-Gilloise that secured a place in the last 16.
Aston Villa's Premier League title challenge suffered a huge blow in a 1-0 defeat against Everton, while Newcastle's push towards the top four was derailed by a 0-0 draw at Wolves on Sunday.
Semenyo also scored on his debut on Saturday in a 10-1 demolition of Exeter in the FA Cup.
Patrick Dorgu's first Manchester United goal earned the depleted Red Devils a 1-0 win over Newcastle to propel Ruben Amorim's men up to fifth in the Premier League.
Here are the live streaming and live telecast details of Manchester United vs Newcastle United, Premier League 2025-26 match -
Aston Villa face a tough challenge at Chelsea on Saturday after muscling their way into the Premier League title race alongside Arsenal and Manchester City.