Sunderland compounded a miserable week for Newcastle as Bryan Brobbey's 90th minute winner secured a 2-1 victory for the visitors in the Tyne-Wear derby on Sunday.
Robert Lewandowski and Raphinha struck twice each for the Catalan giants as Newcastle crumbled under a scintillating attacking display from the hosts at Camp Nou.
Barcelona vs Newcastle United Live Streaming, Champions League Round Of 16 LIVE Telecast: When And Where To Watch
Lamine Yamal's penalty with the last kick of the game rescued Barcelona from defeat at Newcastle in a 1-1 Champions League last 16, first leg draw on Tuesday.
Newcastle vs Barcelona LIVE Streaming, Champions League Round of 16 LIVE Telecast: When And Where To Watch
Hansi Flick has warned Barcelona that Newcastle pose a serious threat to their Champions League ambitions as a product of "the best league in the world".
Manchester City shrugged off 10 changes to their starting line-up to crush Newcastle 3-1 and reach the FA Cup quarter-finals on Saturday as Chelsea battled past 10-man Wrexham.
Real Madrid and Manchester City will face off in a Champions League knockout tie for the fifth season running.
Newcastle United completed their stroll into the Champions League last 16 with a 3-2 win over Qarabag on Tuesday to progress 9-3 on aggregate over the Azeri champions.
Nico O'Reilly scored both goals for Pep Guardiola's team and extended Manchester City's unbeaten run in the league to five.
Norway's Bodo/Glimt stunned Inter Milan in the Champions League on Wednesday, beating last season's runners-up 3-1 in the first leg of their knockout phase play-off tie.
Mansfield produced the only shock of note so far in the fourth round by coming from behind to win 2-1 at top tier Burnley on Saturday.
Liverpool advanced to the fifth round of the FA Cup by defeating Brighton & Hove Albion 3-0 at Anfield.
Benjamin Sesko salvaged a 1-1 draw for Manchester United at West Ham as Michael Carrick's perfect start came to an end on Tuesday.
Manchester City will face Arsenal in the League Cup final after ending Newcastle's reign as holders with a first-half blitz in their 3-1 victory.
Title-holders Paris Saint-Germain and Newcastle United will both go into the Champions League play-off round after playing out a 1-1 draw in their final match of the league phase on Wednesday.
Aston Villa closed to within four points of the Premier League summit with an impressive 2-0 win at Newcastle.
Liverpool eased to a 3-0 win in Marseille in the Champions League as Harry Kane's double earned Bayern Munich a 2-0 victory against Union Saint-Gilloise that secured a place in the last 16.