Newcastle United have not won a major domestic prize since winning the FA Cup in 1955.
Newcastle United reignited their bid to qualify for the Champions League as Bruno Guimaraes sealed a controversial 1-0 win at West Ham on Monday.
Danny Welbeck sent Brighton into the FA Cup quarter-finals as his extra-time strike clinched a dramatic 2-1 win against Newcastle in a stormy clash scarred by red cards for both teams.
Manchester City face Plymouth Argyle, who shocked Liverpool, whilst Manchester United take on Fulham.
Liverpool moved a giant step closer to the Premier League title with a ruthless 2-0 win against Newcastle, while Arsenal's challenge is in tatters after a 0-0 draw against Nottingham Forest.
Eddie Howe hailed Newcastle's "huge" League Cup semi-final win against Arsenal as the Magpies boss vowed his side would learn from the pain of their last visit to Wembley
Darwin Nunez struck twice in stoppage time to earn Liverpool a 2-0 win at Brentford and open up a seven-point Premier League lead on Saturday after Bournemouth ran riot in a 4-1 win at Newcastle.
Newcastle took a giant stride towards the League Cup final as goals from Alexander Isak and Anthony Gordon earned a 2-0 semi-final, first leg lead atArsenal.
Erling Haaland scored twice as Manchester City pummelled West Ham 4-1 in the Premier League on Saturday while in-form Newcastle inflicted another painful defeat on Ange Postecoglou's struggling Tottenham.
Thomas Tuchel will mark the official start of his England reign by watching Tottenham play Newcastle in the Premier League on Saturday.
Arsenal will take on Newcastle United in the other semi-final.
The Reds sit five points clear of second-placed Chelsea, who can close the gap with a win against Brentford at Stamford Bridge on Sunday.
Manchester United manager Ruben Amorim insists he did not speak to Manchester City about replacing Pep Guardiola at the Etihad Stadium before making his move to Old Trafford.
Manchester's crisis-hit clubs face off in the Premier League when City host United on Sunday
Mohamed Salah's second-half double was not enough to extend Liverpool's seven-game winning run in all competitions as they failed to win for just the third time in 21 games under Arne Slot.
West Ham produced a clinical away performance to beat resurgent Newcastle 2-0 on Monday, easing the pressure on beleaguered manager Julen Lopetegui.
Mikel Arteta's men have now picked up just one point in their past three games as their title push quickly runs out of steam.
Manchester City's second successive draw in the league was especially frustrating as Arsenal moved level on points with them with a last-gasp 4-2 win against Leicester a few hours later.