Aston Villa beat crisis-hit Manchester City 2-1 on Saturday to heap more misery on floundering manager Pep Guardiola, who has now suffered nine defeats in his past 12 matches.
Chelsea take on Everton, while Liverpool face a tough tie against Tottenham.
An 85th-minute goal from Ross Barkley took Aston Villa to a 3-2 win at RB Leipzig on Tuesday, sending the visitors third in the table and boosting their hopes of a top-eight finish
Liverpool have barely put a foot wrong in the Premier League either, surging into an eight-point lead after just 12 games.
Liverpool beat Real Madrid 2-0, while Aston Villa saw a stoppage time goal disallowed.
Arsenal got their Premier League title challenge back on track with a 3-0 win over Nottingham Forest on Saturday as Chelsea moved up to third by beating Leicester 2-1.
Aston Villa's Morgan Rogers is among a group of five players added to England's squad for this month's Nations League fixtures against Greece and Ireland
Manchester City slumped to a fourth consecutive defeat after blowing the lead to lose 2-1 at Brighton
Unai Emery says he is not worried about Aston Villa's dip in form and believes they are competitive enough to finish in the Premier League's top four.
Injury-hit Manchester City are desperate to snap their losing streak in their final Premier League game before the international break.
Dominic Solanki scored twice as Tottenham blitzed Aston Villa in the second half on Sunday, winning 4-1 to move just two points behind their rivals for a top-four finish in the Premier League.
Erling Haaland fired Manchester City to the top of the Premier League as the striker sealed a 1-0 win against Southampton
John McGinn said there is no limit to Aston Villa's ambition in the Champions League after beating Bologna 2-0 to go top of the table in a dream return to the competition.
Duran has scored six times this season.
Manchester United's winless run stretched to five games in a 0-0 draw at Aston Villa on Sunday that did little to ease the pressure on Erik ten Hag.
Bayern Munich had not lost a Champions League group game since 2017 until a 1-0 defeat to Aston Villa on Wednesday night.
Aston Villa repeated their famous 1982 European Cup final win over Bayern Munich as Jhon Duran's winner beat the German giants 1-0 on Wednesday.
Aston Villa vs Bayern Munich LIVE Telecast, UEFA Champions League 2024-25 LIVE Streaming