Aston Villa manager Unai Emery says his team are "very motivated" to secure direct qualification for the Champions League last 16 heading into Tuesday's crucial game
Arsenal's Premier League title hopes suffered a major setback as they blew a two-goal lead in a damaging 2-2 draw against Aston Villa on Saturday.
Aston Villa bolstered their attacking options on Tuesday with the signing of Dutch international Donyell Malen from Borussia Dortmund.
Despite leading till the 70th minute, West Ham went on to lose 2-1.
Aston Villa beat crisis-hit Manchester City 2-1 on Saturday to heap more misery on floundering manager Pep Guardiola, who has now suffered nine defeats in his past 12 matches.
Chelsea take on Everton, while Liverpool face a tough tie against Tottenham.
An 85th-minute goal from Ross Barkley took Aston Villa to a 3-2 win at RB Leipzig on Tuesday, sending the visitors third in the table and boosting their hopes of a top-eight finish
Liverpool have barely put a foot wrong in the Premier League either, surging into an eight-point lead after just 12 games.
Liverpool beat Real Madrid 2-0, while Aston Villa saw a stoppage time goal disallowed.
Arsenal got their Premier League title challenge back on track with a 3-0 win over Nottingham Forest on Saturday as Chelsea moved up to third by beating Leicester 2-1.
Aston Villa's Morgan Rogers is among a group of five players added to England's squad for this month's Nations League fixtures against Greece and Ireland
Manchester City slumped to a fourth consecutive defeat after blowing the lead to lose 2-1 at Brighton
Unai Emery says he is not worried about Aston Villa's dip in form and believes they are competitive enough to finish in the Premier League's top four.
Injury-hit Manchester City are desperate to snap their losing streak in their final Premier League game before the international break.
Dominic Solanki scored twice as Tottenham blitzed Aston Villa in the second half on Sunday, winning 4-1 to move just two points behind their rivals for a top-four finish in the Premier League.
Erling Haaland fired Manchester City to the top of the Premier League as the striker sealed a 1-0 win against Southampton
John McGinn said there is no limit to Aston Villa's ambition in the Champions League after beating Bologna 2-0 to go top of the table in a dream return to the competition.
Duran has scored six times this season.