A goal and an assist from Xavi Simons and a Lois Openda brace helped RB Leipzig thump Cologne 5-1 away on Friday to leapfrog Borussia Dortmund into the top four.
Borussia Dortmund are a club heavily dependent on the income the Champions League brings, and have only missed the top four once in the past 13 years.
The UEFA Champions League quarter-final draw will be held on Friday in Nyon, at 4:30 PM IST.
A third-minute goal from Jadon Sancho and Marco Reus' late strike sent Borussia Dortmund through to the Champions League last eight.
Borussia Dortmund's coach and sporting director both praised Jadon Sancho after the England winger's goal secured a 2-1 win at Werder Bremen on Saturday.
PSV Eindhoven coach Peter Bosz was left ruing missed chances after his side squandered several opportunities in a 1-1 draw with Borussia Dortmund in the Champions League.
Donyell Malen scored a first-half brace as Borussia Dortmund eased to a 3-0 home victory over Freiburg in the Bundesliga on Friday
Bayern Munich's injury crisis worsened on Saturday after defender Alphonso Davies suffered a ligament strain in his knee
Injury-hit Borussia Dortmund were held to a goalless draw at Heidenheim on Friday, dropping crucial points in their bid for Champions League football next season.
A hat-trick from Niclas Fuellkrug powered Borussia Dortmund to a 3-1 win over Bochum on Sunday
Exequiel Palacios scored in the fourth minute of injury time to earn Bundesliga leaders Bayer Leverkusen a 1-0 win at Augsburg on Saturday
Ian Maatsen impressed on loan at Burnley last season, scoring four times and laying on six assists in 42 appearances as he helped the side win promotion to the Premier League.
Jadon Sancho had been frozen out at United for most of the season after becoming involved in a public spat with manager Erik ten Hag
Borussia Dortmund were held to a 1-1 home draw with lowly Mainz in the Bundesliga on Tuesday, continuing their struggles and deepening coach Edin Terzic's woes
Despite topping their Champions League group, Borussia Dortmund have won just one of seven league games since October.
Paris Saint-Germain take on Borussia Dortmund in Germany on Wednesday in their final group-stage game with more than just Champions League survival hanging in the balance
Leaders Bayer Leverkusen retain their three-point cushion and travel to third-place Stuttgart on Sunday on a weekend when six of the Bundesliga's top seven face each other.
Dortmund manager Edin Terzic praised his team's defence in the "fair result", but hit out at VAR, who declined to intervene despite what seemed like a late foul on winger Karim Adeyemi.