Lionel Messi, who has missed the beginning of the season with a calf injury, was named in Barcelona's squad for their Champions League clash.
Jadon Sancho fed Paco Alcacer for Dortmund's opener just after the break before clinching the victory and his side's first trophy since 2017 with a clinical finish.
Liverpool face Spanish side Sevilla on Sunday at Boston's Fenway Park baseball stadium in the second game of their three-match US tour.
The initial proposals envisaged a single, three-tiered European competition with internal promotion and relegation, effectively making it harder for smaller clubs to break into European competition.
League leaders Bayern Munich currently sit two points ahead of rivals Borussia Dortmund with three games to go.
The defeat to Schalke severely harmed Borussia Dortmund's title hopes, handing Bayern Munich the chance to go four points clear with three games to go.
The young striker has been making waves in Borussia Dortmund's youth system, scoring 36 goals in 21 games for the Under-17 team this season.
This is the first time Tottenham Hotspur are in the last eight of the Champions League since 2010/11.
Mauricio Pochettino said that Jadon Sancho had been on his radar for a while before he started making headlines.
Manchester City midfielder Ilkay Gundogan was a member of the Borussia Dortmund side that Klopp guided to the 2nd of two Bundesliga championships in 2012.
Borussia Dortmund twice came from behind to beat defending champions Bayern Munich 3-2.
Barcelona's 2-0 win over Inter Milan left them on the brink of a spot in the Champions League last 16.
Jadon Sancho has appeared as a substitute in each of Dortmund's six Bundesliga outings this season.
Dortmund said that Witsel had activated his release clause -- reported to be around 20 million euros (23 million US dollars).
Real Kashmir FC earlier became the first football club from Jammu and Kashmir to qualify for the country's top tier I-League.
Riyad Mahrez, the $75 million signing from Leicester, made his Manchester City debut while the precocious young English midfielder Phil Foden also started.
Usain Bolt had expressed his desire to become a professional footballer.
Bolt, an eight-time Olympic gold medallist, will captain the Soccer Aid World XI in a match to raise funds for the United Nations Children's Fund, Unicef.