Inter Miami coach Guillermo Hoyos said after the game it was too early to determine if Messi was injured, and suggested the Argentine's substitution was precautionary due to the pitch conditions.
As per De Paul, Messi, who also captains Inter Miami, has a double training session as a part of his daily routine, which is beyond his standard commitments with the club.
Lionel Messi's goal and dazzling assist finally earned Inter Miami a first win at their new stadium Sunday, beating the Portland Timbers 2-0.
Lionel Messi scored twice and had a hand in two others as Inter Miami fought back to beat FC Cincinnati 5-3 away in the MLS on Wednesday.
Lionel Messi more than doubled his salary to $25 million (approx. Rs 257 crore) in his new contract with Inter Miami and earns more more than twice as much as the second-highest-paid player in Major League Soccer, Los Angeles FC's Son Heung-min.
Lionel Messi scored one goal and set up two more as Inter Miami got back to winning ways with a 4-2 defeat of Toronto FC in Major League Soccer on Saturday.
Argentina captain Lionel Messi, accompanied by Inter Miami teammates Luis Suarez and Rodrigo de Paul, was evacuated from the stadium in 25 minutes due to crowd trouble and vandalism in Kolkata
Lionel Messi's Inter Miami squandered a 3-0 lead to fall 4-3 to Orlando City on Saturday and remain in search of a first win at their new Nu Stadium.
It was the fastest two goals in club history at one minute and 54 seconds.
Lionel Messi gifted Inter Miami's new coach a 3-2 victory over the Colorado Rapids with a brace including a spectacular late winner in front of 75,000 Major League Soccer fans on Saturday.
Lionel Messi marked the opening of Inter Miami's gleaming new stadium with a goal as the Major League Soccer champions battled to a 2-2 draw against Austin FC on Saturday.
The Nu Stadium is a permanent, purpose-built replacement for Inter Miami's temporary home at Chase Stadium in Fort Lauderdale, where the club have played since joining MLS in 2020.
Lionel Messi scored his 901st career goal and Inter Miami delivered New York City's first loss of the Major League Soccer season on Sunday with a 3-2 triumph.
Lionel Messi bagged the 900th goal of his glittering career on Wednesday but could not prevent Inter Miami from crashing out of the CONCACAF Champions Cup on away goals after a 1-1 draw with Nashville.
Lionel Messi was denied his 900th career goal on Wednesday as reigning MLS champion Inter Miami played a 0-0 draw at Nashville in the CONCACAF Champions Cup.
Lionel Messi scored in the 27th minute, and Inter Miami held on for a 2-1 victory over D.C. United on Saturday night in front of 72,026 at the home of the Baltimore Ravens.
Lionel Messi scored twice as Inter Miami fought back from 2-0 down to complete a 4-2 victory over Orlando City in Major League Soccer's Florida derby on Sunday.
Soccer star Lionel Messi was knocked to the ground by a fan and a security guard at the end of Inter Miami's friendly match in Puerto Rico.