Brentford avoided a huge FA Cup shock with a 1-0 win at sixth-tier Macclesfield on Monday but needed a late own goal to beat a side 116 places below them in the English football pyramid.
Mansfield produced the only shock of note so far in the fourth round by coming from behind to win 2-1 at top tier Burnley on Saturday.
Arsenal missed the chance to extend their Premier League lead to six points as Brentford rattled the Gunners in a 1-1 draw on Thursday to give Manchester City hope in the title race.
Aston Villa boss Unai Emery blasted a VAR intervention to rule out a goal for his side as Sunday's 1-0 home defeat to 10-man Brentford dented their dreams of winning the Premier League title.
Benjamin Sesko rode to Manchester United's rescue in another thrilling 3-2 win for Michael Carrick's men over Fulham on Sunday, as Aston Villa's Premier League title challenge faltered in defeat to 10-man Brentford.
Thomas Frank said the "boring Tottenham" taunts from his own club's fans were understandable after they were held to a dour 0-0 draw by Brentford on Thursday.
Manchester City trail Arsenal by four points at the top of the Premier League after failing to end Sunderland's unbeaten home record in a 0-0 draw on Thursday, while Liverpool were also held by Leeds.
Rayan Cherki's stunning strike put Manchester City on their way to the League Cup semi-finals with a 2-0 win over Brentford, while holders Newcastle beat Fulham 2-1 on Wednesday.
Liverpool needed a late own-goal to salvage a 1-1 draw with Sunderland at Anfield, whilst Chelsea suffered a shock 3-1 defeat to relegation-battling Leeds United.
Throughout the 90 minutes against Liverpool, Brentford played 62 long passes, their highest tally in the ongoing season.
Liverpool have lost five of their last six games in all competitions despite a Premier League record expenditure in the transfer window.
West Ham lost for the fourth home match in a row in the Premier League on Monday, with late goals in both halves giving Brentford a 2-0 win.
Erling Haaland extended his blistering start to the season as the Manchester City striker sealed a 1-0 win at Brentford on Sunday.
Liverpool's perfect Premier League start came undone in a 2-1 defeat at Crystal Palace on Saturday as Manchester United suffered another setback...
Keith Andrews' Brentford drew 1-1 with Aston Villa before winning 4-2 on penalties in west London.
Chelsea missed the chance to go top of the Premier League as Fabio Carvalho's 93rd minute equaliser salvaged a 2-2 draw for Brentford in Saturday's west London derby.
Wissa, a reported target for Newcastle, is yet to play for Brentford this season and had already removed any association with the club from his Instagram account.
A costly error by Manchester United goalkeeper Altay Bayindir handed Arsenal victory.