Denmark claimed the spoils, with goals either side of the break by Joakim Maehle and Thomas Delaney.
Manchester United could be without Rasmus Hojlund for a critical Champions League trip to Galatasaray, while Christian Eriksen will be sidelined for a month in the latest injury blow to the Red Devils.
Reigning champions Italy eased to a 4-0 victory over Malta in Euro 2024 qualifying on Saturday
Australia secured a place in the quarter-finals of the Women's World Cup with a 2-0 win over Denmark on Monday.
Rasmus Hojlund joined Atalanta in August 2022 from Austrian club Sturm Graz for a reported 17 million euros. He scored nine goals in 32 appearances in Serie A last season.
China are level with Denmark on three points in Group D, with England leading on six but their place in the last 16 still not assured.
England stood on the brink of the Women's World Cup last 16 after a Lauren James cracker in the sixth minute gave them a 1-0 win over Denmark.
Denmark ended a 16-year Women's World Cup absence with victory as a 90th-minute header from Amalie Vangsgaard broke China's hearts in Perth on Saturday
Harry Kane scored again as England made it two wins from two in Euro 2024 qualifying by beating Ukraine 2-0 at Wembley on Sunday, while Denmark were defeated by Kazakhstan.
A 60th-minute goal from Mathew Leckie secured a battling win for Australia, who advanced to the knockout rounds after finishing second in Group D behind reigning champions France.
FIFA World Cup 2022, Tunisia vs France, Australia vs Denmark Highlights: Australia join France in the Round of 16 with a 1-0 win over Denmark. Les Bleus were stunned 1-0 by Tunisia.
In the Group D of FIFA World Cup 2022, France have already qualified for the Round of 16. One team among Australia, Denmark and Tunisia will join them on Wednesday.
France coach Didier Deschamps insisted he was never worried his side might be the latest defending champions to be eliminated from the World Cup in the group stage after they became the first team through to the last 16.
Having scored four during France's victorious 2018 campaign and one against Australia, Mbappe now has seven goals in nine World Cup appearances.
FIFA World Cup 2022, France vs Denmark Highlights: Kylian Mbappe scored twice as France became the first team into the last 16 of the World Cup with a 2-1 victory over Denmark on Saturday
Denmark midfielder Thomas Delaney is out of the World Cup after picking up a knee injury during his team's opening goalless draw with Tunisia, the country's FA announced on Wednesday.
Christian Eriksen was largely anonymous on his return to major tournament football after nearly dying on the pitch at the European Championship last year, wilting in the face of ferocious defending.
FIFA World Cup 2022, Denmark vs Tunisia Highlights: Tunisia put in a great defensive display to secure a goalless draw against Denmark in Group D.