Rasmus Hojlund fired Napoli top of Serie A with both goals in Sunday's 2-1 win over Juventus and former idol Luciano Spalletti, who left empty-handed from the site of his greatest triumph.
David Neres stroked home the only goal of a feisty game in the 36th minute at the Stadio Olimpico, as Napoli beat Roma 1-0.
Roma are surprise leaders of Serie A heading into Sunday's clash with Napoli, a fixture which will go some way to showing whether Gian Piero Gasperini's side are the real deal.
Milan takes centre stage on Sunday night as the city's two football giants face off at the San Siro with top spot in Serie A up for grabs.
Italian champions Napoli came unstuck at Bologna on Sunday, losing 2-0 to cede the Serie A summit to Inter Milan who downed Lazio by the same scoreline.
Antonio Conte's Napoli lost 2-0 at Bologna on Sunday as it failed to score for a third successive match despite its opponent playing with a teenage, third-choice goalkeeper.
AC Milan are level with Napoli at the top of Serie A after throwing away a two-goal lead to draw 2-2 on Saturday in an entertaining match at lowly Parma.
Inter Milan were handed a 2-1 win at Verona by a late own goal on Sunday to move to within a point of stuttering Serie A leaders Napoli.
Napoli maintained their lead at the top of Serie A on Tuesday after the champions won a hard-fought contest at lowly Lecce 1-0 and moved three points ahead of AC Milan.
Belgian midfielder Kevin De Bruyne has suffered a severe lesion to his thigh muscle and will be sidelined for several months.
Kevin de Bruyne appeared to pull a muscle as he converted a first-half penalty, immediately clutching the back of his right thigh.
Tuesday's 6-2 defeat in the Netherlands was fully deserved for Napoli, and came after last weekend's shock loss at Torino which led to AC Milan taking top spot in Italy's top flight.
Inter Milan moved top of Serie A on goal difference on Saturday after winning 1-0 at Roma, taking advantage of Napoli's shock 1-0 defeat at Torino.
Rasmus Hojlund struck again for Napoli with the winning goal in Sunday's 2-1 victory over struggling Genoa.
Napoli lead the Serie A pack with a perfect 12 points from their first four matches of the league campaign.
Luka Modric and Kevin De Bruyne will face off on Sunday night when Serie A champions Napoli travel north to face AC Milan and the first true test of their title defence.
Napoli maintained their lead at the top of Serie A with Monday's 3-2 win over promoted Pisa which continued the champions' perfect start to their domestic campaign.
Kevin De Bruyne was sacrificed as Napoli coach Antonio Conte reorganized his team after going down to 10 men.