Juventus head to Milan having lost just one of their last 10 matches but Inter have won their last five league games.
Como advanced to the semi-finals of the Coppa Italia for the first time in 40 years after beating Italian champion Napoli in a penalty shootout on Tuesday.
Rasmus Hojlund's penalty deep into added-on time snatched a 3-2 victory at Genoa on Saturday and kept champions Napoli hanging on in the Serie A title race.
Italian champions Napoli edged lowly Fiorentina 2-1 in Serie A on Saturday to keep pace in the title race, three days after being dumped out of the Champions League.
Joao Pedro fired Chelsea into the last 16 of the Champions League with a brace in Wednesday's 3-2 win at Napoli which secured a top-eight finish and eliminated their Italian opponents.
Napoli are on the brink of being eliminated from the Champions League as the troubled Italian club face Chelsea on Wednesday racked by a deep injury crisis and a faltering Serie A title defence.
Trailing leaders Inter Milan by six points ahead of their trip to Turin, Napoli have to pick themselves up after a poor 1-1 draw at 10-man FC Copenhagen.
Lautaro Martinez fired Inter Milan six points clear at the top of Serie A with the only goal in Saturday's 1-0 win at Udinese, as Napoli responded to the pressure by beating Sassuolo 1-0.
Inter Milan moved six points clear at the top of Serie A on Wednesday after beating Lecce 1-0 and taking advantage of Napoli's goalless draw with Parma.
Scott McTominay kept Napoli in touch with Serie A leaders Inter Milan with a brace in Sunday's entertaining 2-2 draw at the San Siro, after AC Milan were held to a 1-1 draw at Fiorentina.
Inter Milan moved four points clear at the top of Serie A on Wednesday after winning 2-0 at Parma while rivals Napoli battled to a 2-2 home draw with Verona.
Napoli came back from two goals down to draw 2-2 with lowly Verona on Wednesday, a result which gave Inter Milan the chance to pull away from the champions in the race for the Serie A title.
Defending champion Napoli recorded a comfortable 2-0 win at Lazio to move second in Serie A on Sunday as it continued its good form from the end of 2025.
It is the third time Napoli have won the competition, after 1990 and 2014.
Napoli downed AC Milan 2-0 in Thursday's Italian Super Cup semi-final in Riyadh.
Champions Napoli squandered the chance to climb to the Serie A summit on Sunday when coming unstuck 1-0 at Udinese.
Rasmus Hojlund fired Napoli top of Serie A with both goals in Sunday's 2-1 win over Juventus and former idol Luciano Spalletti, who left empty-handed from the site of his greatest triumph.
David Neres stroked home the only goal of a feisty game in the 36th minute at the Stadio Olimpico, as Napoli beat Roma 1-0.