For a second successive league game, the Gunners had failed to hold onto a lead following their 1-1 draw at Brentford last Thursday.
Arsenal's Premier League title challenge suffered a major blow as they squandered a two-goal lead and conceded a stoppage-time equaliser in a damaging 2-2 draw at rock-bottom Wolves.
Mansfield produced the only shock of note so far in the fourth round by coming from behind to win 2-1 at top tier Burnley on Saturday.
Nottingham Forest sacked manager Sean Dyche on Wednesday after a dismal home draw with Wolves left them hovering three points above the Premier League relegation zone.
Liverpool won the race to sign Rennes defender Jeremy Jacquet on a quiet final day of the Premier League transfer window, while Crystal Palace swooped for Wolves striker Jorgen Strand Larsen despite the collapse of Jean-Philippe Mateta's move to AC Milan.
Pep Guardiola said his success at Manchester City has come in spite of refereeing decisions going against his side in a tirade following Saturday's 2-0 win over Wolves.
Thomas Frank's job is under renewed threat after Tottenham dropped more points in a 2-2 draw at relegation-threatened Burnley on Saturday as Manchester City cut the gap to Premier League leaders Arsenal to four points.
Manchester United boss Ruben Amorim said his side "lacked quality" to break down a Wolves team without a Premier League win all season in the latest blow to their chances of Champions League football next season.
Diogo Jota's children served as mascots during the Premier League match between Liverpool and Wolves as the two clubs paid tribute to the former Portugal footballer, who was killed in a car accident
Arsenal avoided a major embarrassment against Premier League bottom club Wolves on Saturday.
Manchester United secured a 4-1 victory over Wolves with Bruno Fernandes scoring twice, moving within one point of the top four in the Premier League.
Rob Edwards has been tasked with performing the great escape for Wolverhampton Wanderers in the Premier League.
Chelsea quelled criticism of Enzo Maresca's rotation policy with a 3-0 win against Wolves featuring the first goal of Malo Gusto's career on Saturday.
Wolverhampton Wanderers sacked head coach Vitor Pereira on Sunday after failing to win any of their opening 10 Premier League games.
Chelsea boss Enzo Maresca blasted Liam Delap for a "stupid" and "embarrassing" red card in Wednesday's 4-3 win at Wolves in the League Cup fourth round.
Newcastle beat Nottingham Forest 2-0 to extend Ange Postecoglou's wait for a win, while Crystal Palace's 19-game unbeaten run was ended by Jack Grealish's late winner for Everton on Sunday.
Tottenham Hotspur needed a 94th-minute goal to avoid defeat against Wolverhampton Wanderers.
A Martin Zubimendi double took Arsenal top of the Premier League as Ange Postecoglou's first game in charge of Nottingham Forest ended in a 3-0 defeat.