In a stunning performance, the 110th-ranked Yuki Bhambri dispatched the ninth seeded Frenchman 6-4, 6-4 in an hour and 19 minutes.
Novak Djokovic will face another Frenchman, Gael Monfils, for a place in Sunday's US Open final after the 10th seed downed compatriot Lucas Pouille 6-4, 6-3, 6-3
Gael Monfils and Angelique Kerber both reached the US Open semifinals on Tuesday after securing easy wins in their singles quarterfinal matches
Lucas Pouille is in the quarter-finals of a second straight Grand Slam, having also reached the last eight at Wimbledon 2016
Rafael Nadal, the winner of 14 majors, suffered a
Rafael Nadal, who hasn't reached a major quarter-final since Roland Garros last year, was defeated in five sets by Frenchman Lucas Pouille in the US Open fourth round match
Rafael Nadal looked in fine form in a 6-1, 6-4, 6-2 victory over Russian Andrey Kuznetsov in the US Open third round
Tomas Berdych is one win away from reaching his second Grand Slam final, six years after losing to Rafael Nadal in the Wimbledon title match
Tomas Berdych called for more player power in deciding whether to carry on playing in fading light
Roger Federer, after showing signs of fatigue in the second, took a quick break before the third, and then went on a roll to set up three match points in the ninth game.