Rohan Bopanna now has the opportunity to secure a place in a Grand Slam men's doubles final for the second time in his career
Veteran duo Julien Benneteau and Nicolas Mahut secured France's decisive win, beating Feliciano Lopez and Marcel Granollers 6-0, 6-4, 7-6 (9/7).
World No.1 Serena Williams dominated Sweden's Johanna Larsson 6-2, 6-1 in the US Open third round match to surpass Martina Navratilova for most Grand Slam wins by a woman with 307 victories
It was the second Grand Slam title for the top-ranked pair of Pierre-Hugues Herbert and Nicholas Mahut after their triumph in the 2015 US Open
Rohan Bopanna and Nicolas Mahut needed just 50 minutes to dispatch their unseeded rivals Robin Hasse and Guillermo Garcia-Lopez in the opening round of the 635,645 Euro ATP 250 event
Mahut and Herbert, Australian Open runners-up earlier this year, won their first Grand Slam doubles crown and became the first all-French duo to capture a US Open men's doubles title.
The 31-year old Nicolas Mahut captured the title at the Hall of Fame Tennis Championships on Sunday, beating Lleyton Hewitt of Australia 5-7, 7-5, 6-3.
The second-seeded Isner, listed at 6-foot-9, served 23 aces, including three in each of the tiebreaks. The 6-foot-10 Karlovic had 14 aces, but double faulted on match point.
Russell lost the first three points of the deciding tiebreaker before rallying to reach his second career ATP semifinal. He raised both arms in triumph when Sijsling hit a backhand return long and wide.
It was a Wimbledon rematch for the pair. Isner retired in the third game of the previous match last month after injuring his left knee.