Veteran duo Julien Benneteau and Nicolas Mahut secured France's decisive win, beating Feliciano Lopez and Marcel Granollers 6-0, 6-4, 7-6 (9/7).
World No.1 Serena Williams dominated Sweden's Johanna Larsson 6-2, 6-1 in the US Open third round match to surpass Martina Navratilova for most Grand Slam wins by a woman with 307 victories
It was the second Grand Slam title for the top-ranked pair of Pierre-Hugues Herbert and Nicholas Mahut after their triumph in the 2015 US Open
Rohan Bopanna and Nicolas Mahut needed just 50 minutes to dispatch their unseeded rivals Robin Hasse and Guillermo Garcia-Lopez in the opening round of the 635,645 Euro ATP 250 event
Mahut and Herbert, Australian Open runners-up earlier this year, won their first Grand Slam doubles crown and became the first all-French duo to capture a US Open men's doubles title.
The 31-year old Nicolas Mahut captured the title at the Hall of Fame Tennis Championships on Sunday, beating Lleyton Hewitt of Australia 5-7, 7-5, 6-3.
The second-seeded Isner, listed at 6-foot-9, served 23 aces, including three in each of the tiebreaks. The 6-foot-10 Karlovic had 14 aces, but double faulted on match point.
Russell lost the first three points of the deciding tiebreaker before rallying to reach his second career ATP semifinal. He raised both arms in triumph when Sijsling hit a backhand return long and wide.
It was a Wimbledon rematch for the pair. Isner retired in the third game of the previous match last month after injuring his left knee.
Tim Smyczek defeated fellow American Sam Querrey in the opening round of the Hall of Fame Tennis Championships 6-4, 7-6 (8) on Tuesday on Newport's grass courts.
Mahut was given a wild card entry for Wimbledon, which gets underway on Monday, and will play Czech Jan Hajek in the first round.
The 100th-ranked Johnson will be playing in the singles at the grass-court Grand Slam tournament for the first time since becoming a full-time professional last summer. He won the ATP Challenger title at Nottingham last week to earn his wild card, which was announced on Tuesday.
Murray had to complete two matches in one day after heavy rain on Wednesday left the pre-Wimbledon warm-up event behind schedule.
Murray had suffered a shock defeat against Mahut at the same stage of the pre-Wimbledon warm-up event 12 months ago, but the US Open champion's dominant display ensured there would be no repeat.
Also receiving wild cards were Australia's Matthew Ebden, who won the mixed doubles title at the Australian Open in January with Jarmila Gajdosova, and Germany's Andrea Petkovic.
The Bryans still remember from a decade ago when they could afford to stay in Paris in what was practically only a hole in a wall. When they won the Australian Open this year, they broke a tie for most doubles majors with Australian greats John Newcombe and Tony Roche.
Seventh-seeded Gael Monfils of France continued his successful return after several months out with a knee injury on Thursday, reaching the quarterfinals of the Moselle Open with a 7-6 (4), 7-5 victory over compatriot Nicolas Mahut.