India are sweating on the fitness of superstar batsman Sachin Tendulkar ahead of the second One-Day International against England in Southampton on Tuesday.
Tendulkar missed the first one-dayer in Durham on Saturday with a recurrence of an old toe injury that left him struggling to jog.
The batsman will see a surgeon in Southampton on Monday to determine if he can take any further part in the series.
Rohit Sharma is definitely out of the rest of the series after having his hand fractured by the first ball he faced from Stuart Broad.
Tendulkar aggravated the injury in training on Friday and if he misses the rest of the series it would leave him stranded on 99 international hundreds after failing to get to three figures all summer.
Indian manager Shivlal Yadav said: "He is suffering from inflammation to the bone in his big toe on the right foot. In the past he had a fracture to the bone and after training he felt a little pinch."
The batsman was in visible pain as India's physio treated him on the pitch and about scans later revealed fractures.
The two injuries are the latest in a long list that wrecked India's chances in the Test series where they were beaten 4-0.
Zaheer Khan, Harbhajan Singh, Yuvraj Singh, Gautam Gambir and Ishant Sharma have all been invalided out of the tour leaving MS Dhoni's resources stretched.
England have fitness worries of their own.
Graeme Swann missed the first match because of sickness but captain Alastair Cook is confident he will have his premier spinner back for the second game of the series.
Cook said: "He will be alright for Tuesday."
Dhoni also called for a resolution to the current controversy over the use of Hot Spot in the wake of Rahul Dravid dismissal.
Stuart Broad led the appeals for a caught behind, but Dravid stood his ground whilst Broad asked for the decision to be referred.
Dravid was given not out originally Hot Spot showed nothing, the ball appeared not to move but third umpire Marais Erasmus gave Dravid out on the basis that he heard a noise as the ball passed the bat's edge.
But Dhoni said: "There was nothing on Hot Spot and no deviation and the umpire gave him not out. I thought the benefit of the doubt always went to the batsman.
"I still don't know how he gave him out. There are questions that need to be asked - the benefit of the doubt should go to the batsman."