Marseille's Europa League semi-final tie against Atalanta is finely poised going into the return after the teams drew 1-1 in Thursday's first leg in France.
Canadian star Jonathan David scored his 23rd goal of the season to set Lille on the way to a 3-1 win over Marseille on Friday that kept them firmly on course for next season's Champions League.
Paris Saint-Germain overcame a controversial first-half sending-off to win 2-0 away to bitter rivals Marseille in Ligue 1 on Sunday
Stade Brest, who have never qualified for Europe, are four points better off than fourth-placed Lille, who beat Lens 2-1 on Friday.
Kylian Mbappe has already told PSG that he intends to leave at the end of the current campaign when his contract expires, with Real Madrid his expected next destination.
AC Milan, Marseille, Roma and West Ham were among the other sides to also book their place in Friday's quarter-final draw.
Benjamin Bourigeaud scored a hat-trick for Rennes, including a pair of penalties, but goals from Luka Jovic and Rafael Leao ensured Milan were never really in danger of blowing a 3-0 lead from the first leg.
Kemar Roofe's winner sent Rangers into the Europa League last 16 with a 3-2 victory at Real Betis on Thursday
During the September 24 match between the bitter Ligue 1 rivals, thousands of PSG supporters chanted homophobic slogans referring to their opponents.
The match was originally set for last Sunday, but was called off after the home Marseille fans attacked the Lyon bus as it entered the Stade Velodrome, injuring coach Fabio Grosso.
French football clubs on Monday came under intense pressure to bring their supporters under control after Lyon coach Fabio Grosso suffered cuts to his face when his team's bus was pelted with stones near Marseille's stadium.
Sunday's Ligue 1 match between Marseille and Lyon was postponed after the visitors' bus was stoned on its way to the ground
Liverpool closed in on the Europa League knockout rounds with a 2-0 win over Union Saint-Gilloise on Thursday
Panathinaikos will next face Braga, with the winners to secure their first group-stage appearance in over a decade.
In front of a packed house, Lens also consolidated hopes of qualifying directly for the Champions League ahead of third-placed Marseille, who they leap-frogged with another 2-1 win last week.
PSG are still expected to sweep to the French title and should be too strong for relegation-threatened Troyes on Sunday even if they will be missing Lionel Messi after the World Cup-winning superstar was sanctioned for an unauthorised trip to Saudi Arabia this week.
A record 11th French crown, and ninth since the Qatari takeover of 2011, is now inevitable with PSG claiming a third straight win to ease the pressure on embattled coach Christophe Galtier.
Marseille missed the chance to put some pressure on Ligue 1 leaders Paris Saint-Germain as they were held to a 1-1 home draw by Montpellier on Friday