Real Madrid's nightmare afternoon was made worse by another injury to Eden Hazard, who was forced off in the second half of their 0-1 defeat to Levante.
Lionel Messi had gone four games without a goal in La Liga, his longest drought since 2014.
Eden Hazard's comeback also coincided with Real Madrid conceding twice in a league game for the first time since October, even if they did let in three in the Copa del Rey against Real Sociedad two weeks ago.
A slick Antoine Griezmann strike set Barcelona on their way against Getafe in La Liga on Saturday before they survived a late onslaught from the gritty visitors to win 2-1.
FC Barcelona announced that Ousmane Dembele will be out for six months after undergoing a hamstring surgery.
Lionel Messi set up all three goals as Barcelona came back twice from being a goal down to beat Real Betis.
Barcelona were beaten 0-1 by Athletic Bilbao at San Mames while Real Madrid lost 3-4 in a seven-goal thriller to Real Sociedad at the Santiago Bernabeu.
Ansu Fati, at 17 years and 94 days old, became the youngest player ever to score a brace in La Liga.
Barcelona successfully bounced back from Saturday's surprise La Liga loss away at Valencia by hammering Leganes 5-0 in the Copa del Rey.
Barcelona's defeat to Valencia raised early doubts about Quique Setien's appointment and gave Real Madrid the chance to move three points clear at the top.
Valencia will provide Barcelona's new manager Quique Setien with his first true test and an opportunity to make his mark.
Quique Setien was unveiled at a press conference at the Camp Nou and vowed to stay true to his beliefs in exciting, attacking football.
Spanish champions Barcelona have sacked their coach Ernesto Valverde and appointed Quique Setien as his replacement.
La Liga leaders Barcelona have chalked up a victory over rivals Real Madrid after establishing a record gap between first and second place.
Barcelona's open hankering after Xavi has left a bitter taste, particularly with those who believe Ernesto Valverde, who always speaks with sense and integrity, deserves better.
Barcelona issued a press release saying the surgery on Luis Suarez was for an "injury to the external meniscus of the right knee".
Xavi himself stayed tight-lipped about his "dream" job but his current club, Qatar's Al-Sadd, said that he is in talks with Barcelona to take over as coach.
Five goals in a wild second half saw Atletico Madrid beat Barcelona 3-2 to seal a Super Cup final spot against Real Madrid.