Belgium earned a battling 3-1 win over Russia in Brussels as Eden Hazard struck twice for Roberto Martinez's side.
Ronald Koeman's second game at the helm saw goals from Memphis Depay, Ryan Babel and Virgil van Dijk seal an impressive win.
Memphis Depay is Lyon's biggest signing since the club-record purchase of Yoann Gourcuff from Bordeaux for 22 million euros in 2010
Romelu Lukaku and Dries Mertens as Belgium ran rampant with further goals from Thomas Meunier, Eden Hazard, Yannick Carrasco and an own goal against Estonia to make it four wins from four for the Belgians in 2018 World Cup qualifiers
Pre-match media reports suggested Manchester United F.C. manager Louis van Gaal was one defeat away from the sack and the 64-year-old Dutchman saw his team's run of games without a win extended to seven at a windswept Britannia Stadium.
Jamie Vardy scored in 10th consecutive Premier League game as Leicester has only lost one league game this season under new coach Claudio Ranieri, who took over in the summer after the team won seven of its last nine games last season to survive.
Memphis Depay was handed the famous No. 7 Manchester United jersey after completing his 27.9 million pound move from Dutch outfit PSV Eindhoven in the summer of 2015, but has so far struggled to cope with the demands at Old Trafford.
Manchester United F.C. full-back Luke Shaw suffered a double fracture on his right leg as the Red Devils made their Champions League return with a 2-1 loss against PSV Eindhoven.
Manchester United went behind to an eighth-minute Michael Carrick own goal in Tuesday's first leg at Old Trafford, but Memphis Depay scored two superb goals before teeing up substitute Marouane Fellaini for an injury-time header that put Louis van Gaal's team firmly in control of the tie.
Memphis Depay scored twice in the first half as Manchester United made up for an early own goal by Michael Carrick.
The number has been donned by the likes of Bryan Robson, Eric Cantona, David Beckham and Cristiano Ronaldo previously. Depay was roped in from PSV Eindhoven earlier this summer for a transfer fee of around 22.3 million pounds.
Memphis Depay, who completed a $38.9 million move to Old Trafford, scored for Manchester United as Louis van Gaal's side secured a second consecutive win on their US tour.
Memphis made 124 senior appearances and scored 50 times for PSV Eindhoven after coming through the club's youth system, making his first-team debut in September 2011. The 21-year-old was the Eredivisie's top scorer this season with 22 goals in 30 games (and 28 in 40 games including European matches).
Memphis Depay, the 21-year-old Holland forward, agreed to join United from Dutch champions PSV Eindhoven last week in a deal reportedly worth around £25 million ($38 million, 33.6 million euros).