Atletico Madrid attacker Antoine Griezmann was named vice-captain after Manchester United centre-back Raphael Varane also hung up his boots following the defeat to Argentina in December.
Lloris, who made his international debut as a 21-year-old in a friendly against Uruguay in November 2008, bows out after becoming France's most-capped player during the World Cup.
Aston Villa ruined Tottenham's bid to climb back into the Premier League's top four as a costly mistake from Hugo Lloris condemned the north Londoners to a damaging 2-0 defeat on Sunday
France skipper Hugo Lloris has confirmed that he will not join other European national team captains in wearing an anti-discrimination armband during the World Cup in Qatar
England's Harry Kane and the captains of the seven other nations in the group who have qualified for the World Cup will wear the armbands in Qatar
Tottenham Hotspur manager Antonio Conte expects Hugo Lloris to remain at the London club. The France goalkeeper is out of contract at the end of the season and the Spurs captain will be allowed to talk to foreign clubs about a free transfer from Saturday.
Hugo Lloris hopes France can give Antoine Griezmann a fitting way to celebrate his 100th international appearance by winning the Nations League.
France had not lost a competitive match since a qualifier against Turkey in June 2019, but finished on the losing side in their first shootout since the 2006 World Cup final against Italy.
UEFA Euro 2020: Portugal face Germany in their upcoming Group F encounter, at the Allianz Arena, Munich.
Jose Mourinho said Tottenham's dressing room is divided by "selfish" players and agents who have their own relationships with the press.