USA playmaker Christian Pulisic scored twice in 10 minutes on Monday as AC Milan came from behind to edge Torino 3-2 to move to the summit of Serie A.
AC Milan also had Mike Maignan to thank for the three points as the France goalkeeper kept out Hakan Calhanoglu's penalty in the 74th minute.
AC Milan defeated Lecce 3-0 on Tuesday to book their spot in the last 16 of the Italian Cup thanks to goals by Santiago Gimenez, Christopher Nkunku and Christian Pulisic.
Rafael Leao appeared to injure his right calf after celebrating his headed goal early on and had to be substituted.
Tijjani Reijnders made sure AC Milan got their Champions League campaign up and running with a decisive brace in Tuesday's 3-1 win over 10-man Club Brugge at the San Siro.
AC Milan striker Christian Pulisic is among five players rested from the United States national team ahead of Tuesday's friendly in Mexico
USA were knocked out after a 1-0 loss to Uruguay, as Panama qualified ahead of them after a win over Bolivia.
A moment of madness from Timothy Weah left the USA's Copa America campaign hanging by a thread on Thursday as the hosts crashed to a shock 2-1 defeat to Panama, while Uruguay hammered Bolivia 5-0.
The United States bounced back from their 5-1 defeat to Colombia to earn a morale-boosting 1-1 draw with Brazil in their final warm-up game before the Copa America on Wednesday.
Sunday's win moved Milan three points ahead of third-placed Juventus in the race for Champions League football.