Johanna Konta requested medical attention just a few minutes into her 6-4, 6-4 first round loss to the unseeded Marie Bouzkova.
After torrential rain washed out all of Wednesday's play, the last two women's quarter-finals were played on Thursday with the semi-finals pushed back a day until Friday.
The 23-time Grand Slam winner struggled mightily against the British No. 1.
Venus Williams showed no signs of fatigue to power home 5-7, 6-1, 6-2 in two hours and 19 minutes.
Venus Williams became the oldest Wimbledon finalist for 23 years on Thursday as the American star ended Johanna Konta's history bid with a masterful 6-4, 6-2 win.
Rome Masters winner Zverev shocked by Fernando Verdasco but world No 1 Murray and former French Open champion Wawrinka advance to the second round.
This time last year Johanna Konta, 25, was a largely unknown entity, but her run to the Australian Open last four in 2016 put her on the map and she followed it up with a stellar season that saw her named the WTA's most improved player
Rafael Nadal needed all his trademark grit against Alexander Zverev, 19, dubbed "the future of tennis", and his superior fitness told as he ground out a thrilling 4-6, 6-3, 6-7 (5/7), 6-3, 6-2 win
Both Johanna Konta and Caroline Wozniacki are angling for a maiden Grand Slam title with the winner of their clash on Saturday potentially facing sixth seed Dominika Cibulkova in the Australian Open fourth round and Serena Williams in the quarters.
Johanna Konta, who entered the top 20 of the WTA rankings, suffered a second-round exit at the Nottingham tournament when she lost 4-6, 5-7 to China's Zheng Saisai
Novak Djokovic will be bidding for a record-equalling sixth Australian Open title on Sunday; Serena Williams eyes Steffi Graf's record of 22 Grand Slam titles.
Angelique Kerber reached her maiden Grand Slam final as she ended Johanna Konta's fairy-tale run in the 2016 Australian Open with a 7-5, 6-2 win
Johanna Konta became the first British woman to reach a Grand Slam semi-final since 1983.
Venus Williams, who was the oldest player in the women's draw of the 2016 Australian Open, bowed out in the first round but her opponent, Johanna Konta, said age was irrelevant.
Venus Williams was dumped out of the first round of the Australian Open while Andy Murray cruised into the second round.
Venus Williams suffered a shock first round exit in the 2016 Australian Open as she was thrashed by 47th-ranked British Player Johanna Konta 4-6,2-6
The British number-one-in-waiting began the year ranked 150 but will likely break into the top 50 when the new rankings are released on Monday.
The seven-time Grand Slam-winner survived a three-set examination by qualifier Konta to set up a meeting with Roberta Vinci, Serena Williams' shock conqueror in New York.