Caroline Wozniacki suffered fresh Wimbledon woe as the world number two suffered a shock 6-4, 1-6, 7-5 defeat against Ekaterina Makarova in the second round on Wednesday.
The five-time Grand Slam winner Maria Sharapova racked up eight double faults through the first two sets before swiftly sealing the match in the decider
Germany's Angelique Kerber became the first top seed in French Open history to lose in the opening round when she was knocked out by Russia's Ekaterina Makarova 6-2, 6-2 on Sunday.
This time last year Johanna Konta, 25, was a largely unknown entity, but her run to the Australian Open last four in 2016 put her on the map and she followed it up with a stellar season that saw her named the WTA's most improved player
Rafael Nadal needed all his trademark grit against Alexander Zverev, 19, dubbed "the future of tennis", and his superior fitness told as he ground out a thrilling 4-6, 6-3, 6-7 (5/7), 6-3, 6-2 win
Japanese sixth seed Kei Nishikori quashed German Benjamin Becker's rally attempt, emerging with a 6-1, 6-1, 3-6, 6-3 victory on the new Grandstand court in two hours 10 minutes.
Caroline Garcia and Kristina Mladenovic became the first French duo to win the French Open after 46 years as they defeated Ekaterina Makarova and Elena Vesnina to clinch the women's doubles title.
Defending champion and third seed Maria Sharapova will play world number 23 Makarova in a rematch from last year's Australian Open semifinal.
Ekaterina Makarova lost to Maria Sharapova in the Australian Open semifinals.
World number 1 Serena Williams and her arch-rival Maria Sharapova have bounced back from rather rickety starts to register strong performances in Australian Open. They now may face off against each other in the final.
Simona Halep made the final of the French Open and the semis at Wimbledon last year but said the experience did not help during Tuesday's massacre at Melbourne Park.
Billed as a Glam Slam showdown between two of the game's most marketable women, an intense Maria Sharapova was all business in the crushing 6-3, 6-2 win on a cool, overcast Melbourne day. Sharapova will face dark horse Ekaterina Makarova.
Martina Hingis, 33, was playing with Italy's Flavia Pennetta but despite a promising start to the women's doubles final they went down 2-6, 6-3, 6-2 to fourth seeds Ekaterina Makarova and Elena Vesnina.
World number one Serena Williams, winner of the past two titles at Flushing Meadows and five overall, will try to match Chris Evert and Martina Navratilova on 18 career major titles when she faces her good friend Caroline Wozniacki on Sunday.
This U.S. Open has two final-four debutantes in Peng Shuai and Ekaterina Makarova.
Russians Ekaterina Makarova and Elena Vesnina ended the surprising run of Japanese veteran Kimiko Date-Krumm and Czech partner Barbora Zahlavova Strycova 7-5, 6-3 and will take on Martina Hingis and Flavia Pennetta in the final.
Victoria Azarenka, bidding to reach a third straight Flushing Meadows final, fell 6-4, 6-2 to Russian lefty Ekaterina Makaraova, who reached the first Grand Slam semi-final of her career.
17th-seeded Ekaterina Makarova crafted a 6-4, 6-2 victory over Victoria Azarenka, the No. 16 seed to set up a semifinal meeting with world No.1 Serena Williams.