Opening day will see 2018 champion Simona Halep start her bid for a third major while 40-year-old Venus Williams kicks off her 23rd French Open. Andy Murray takes on Stan Wawrinka in the day's marquee tie.
US Open: Six-time winner Serena Williams powered past 96th-ranked Kristie Ahn after Andy Murray came from two sets down to win a five-set thriller.
Venus Williams, making her 22nd appearance at Flushing Meadows in a career that has spanned four decades, lost 3-6, 5-7 to Karolina Muchova.
Serena Williams said the victory will boost her confidence heading into the US Open as she improved to 19-12 in the 22-year-old rivalry with Venus Williams.
Serena Williams took to Instagram to share a few pictures from her on-court session with her daughter Olympia.
Venus Williams celebrates her 40th birthday on Wednesday with the tennis season on pause amid the coronavirus crisis which has decimated the calendar.
Last month, Dominic Thiem had expressed scepticism about plans to set up a fund to help lower-ranked players struggling because of the shutdown of the sport.
Coco Gauff surged into the second round in Melbourne with a 7-6 (7/5), 6-3 victory over Venus Williams and will play unseeded Romanian Sorana Cirstea next.
Venus Williams pulled out of the season-opening Brisbane International on Wednesday after a "setback" during practice.
Danielle Collins rallied back from 3-5 down in the opening set, winning a whopping nine games in a row to go up 7-5, 5-0 against Venus Williams.
Carlos Ramos will not officiate any US Open matches involving Serena or Venus Williams.
Cori Gauff, 15, is not content with just beating five-time champion Venus Williams -- now she wants to win the Wimbledon title.
15-year-old Cori Gauff pulled off a major upset at Wimbledon, as she knocked out five-time champion Venus Williams 6-4, 6-4.
Roger Federer produced an excellent all-round performance despite being tested by the world number 103 Filip Krajinovic.
Venus Williams rallied from a set and two breaks down to topple third-seeded Petra Kvitova 4-6, 7-5, 6-4 at Indian Wells.
Serena Williams won her 23rd major Down Under two years ago while two months pregnant.
Novak Djokovic defeated Jo-Wilfried Tsonga 6-3, 7-5, 6-4 in straight sets.
The pressure on the reigning French Open champion will only increase in her next round.