Stefanos Tsitsipas was booed after taking more than eight minutes between the third and fourth sets but dominated after his extended toilet trip to beat Adrian Mannarino 6-3, 6-4, 6-7 (4/7), 6-0 at Arthur Ashe Stadium.
Wimbledon 2021: Roger Federer was as his disarming best when he made light of an interviewer's question which the tennis star said had challenged his command on the English language.
Wimbledon 2021: Roger Federer survived a huge Wimbledon scare when French opponent Adrian Mannarino was forced to retire injured at the start of the fifth set of their first round tie with the scores level at 6-4, 6-7 (3/7), 3-6, 6-2 0-0 (15/0).
Novak Djokovic called for the doctor during the second set against Adrian Mannarino but put aside his discomfort to progress 4-6, 6-2, 6-1.
Roger Federer played a fluent forward defensive cricket shot during his Wimbledon match with Adrian Mannarino.
Top seed Roger Federer, 36, has now won 32 consecutive sets at Wimbledon.
Roger Federer survived a surprise test at the Swiss Indoors on Friday before making the semi-finals at his home event for the 14th time with a hard-fought 4-6, 6-1, 6-3 win over Adrian Mannarino.
Novak Djokovic will face the Czech Republic's Tomas Berdych on Wednesday for a semi-final spot, boasting a 25-2 career record over the 2010 Wimbledon runner-up.
Roger Federer, who won five consecutive U.S. Opens from 2004-08, next plays 19th-seeded Tommy Robredo of Spain. Win that, and Federer could face 12-time major champion Rafael Nadal in the quarterfinals in what would be the rivals' 32nd meeting
It was a Wimbledon rematch for the pair. Isner retired in the third game of the previous match last month after injuring his left knee.