Mardy Fish surrendered to Feliciano Lopez in his US Open 2015 match and with it, called time on his career.

Mardy Fish, who has played just a handful of tournaments in the last three years and seen his ranking slip to 581 as he battled his personal demons, lost to Spain's Feliciano Lopez in what became his career's final match.

Mardy Fish has come a long way from his last outing at US Open and is all set to take Flushing Meadows by storm.

Ranked 12th in the world, American John Isner has won two of his nine career titles in Atlanta, where he also lost to Mardy Fish in the 2010 and 2011 finals and to eventual champion Andy Roddick in the 2012 semi-finals.

He has missed months of action at a time over the past two seasons. On Tuesday, Fish stopped playing in the third set of his match against Jarkko Nieminen at a hard-court tournament in Winston-Salem, N.C., because of heat stroke.

Fish will take on Jarkko Nieminen of Finland in the second round of men's final tuneup event before the U.S. Open

While Monfils has withdrawn after injuring his ankle during practice, Fish has cited personal reasons.

It was a Wimbledon rematch for the pair. Isner retired in the third game of the previous match last month after injuring his left knee.

The 31-year-old American has played in just one event since pulling out of the U.S. Open before his fourth-round match last September.

Wimbledon marathon man John Isner, who played in the longest match in history at the All England Club in 2010, was forced to quit his second round match after just two games on Tuesday.