Martina Hingis's hopes of winning her first Grand Slam doubles title since 2002 were shattered on Saturday when the Russian pairing of Ekaterina Makarova and Elena Vesnina took the US Open title.
Hingis, 33, was playing with Italy's Flavia Pennetta but despite a promising start to the final they went down 2-6, 6-3, 6-2 to the fourth seeds.
Hingis last appeared in a doubles final at a Grand Slam in 2002 at the Australian Open where she won the title with Anna Kournikova, one of nine doubles crowns she captured during her heydey.
She also captured the 1998 doubles title in New York with Jana Novotna.
Makarova and Vesnina have now won two majors after their 2013 triumph at the French Open.
Their victory came a day after Makarova was beaten in the singles semi-finals by two-time defending champion Serena Williams.