Premier League: Burnley beat Crystal Palace 1-0 while Southampton and Wolves played out a 1-1 draw.
Pierre-Emerick Aubameyang condemned Manchester United to fresh misery at Old Trafford as the Arsenal forward's penalty clinched a 1-0 win.
Toffees left-back Digne was sent off for a dangerous challenge on Kyle Walker-Peters in the second half, despite his claims he tripped when he stood on the Southampton defender's heel.
Champions League: Chelsea witnessed a goalless draw against Sevilla on Wednesday.
Premier League: Jannik Vestergaard bludgeoned home an added-time equaliser for Southampton from a free-kick that Chelsea failed to clear.
Frank Lampard confirmed Chelsea goalkeeper Edouard Mendy will miss Saturday's Premier League clash against Southampton after a suffering a thigh injury
Tottenham defeated Southampton in the Premier League, with Song Heung-min putting in a talismanic performance.
Pierre-Emile Hojbjerg joined Tottenham Hotspur from Southampton for a reported fee of 15 million pounds.
Ole Gunnar Solskjaer said Manchester United are disappointed with the 2-2 draw against Southampton, but he trusts his team to "put it right".
The 2-2 draw meant Manchester United were unable to take advantage of weekend defeats for Chelsea and Leicester to remain in fifth.