United's second successive loss after their League Cup exit at Tottenham on Thursday underlined Ruben Amorim's belief that their road back to the top will be long and arduous.
Premier League strugglers Southampton announced Saturday they have appointed Ivan Juric as their new manager.
Liverpool moved into the League Cup semi-finals as the holders won 2-1 against managerless Southampton
Premier League basement club Southampton on Sunday sacked manager Russell Martin after an embarrassing 5-0 home defeat to Tottenham.
Southampton still sit 20th in the Premier League table, four points from safety.
Erling Haaland fired Manchester City to the top of the Premier League as the striker sealed a 1-0 win against Southampton
Arne Slot has now won nine of his first 10 games since succeeding Jurgen Klopp as Liverpool manager.
Bhaichung Bhutia Football Schools (BBFS) signed a grassroots development agreement with Premier League club Southampton.
Bournemouth's record signing Evanilson scored his first goal for the club as the Cherries beat Southampton 3-1 on Monday.
Manchester City won an unprecedented fourth Premier League title on the trot, edging Arsenal out by two points, despite failing to beat the Gunners home and away
Manchester United gave manager Erik ten Hag some breathing space with a 3-0 win at Southampton on Saturday thanks to goals from Matthijs de Ligt, Marcus Rashford and Alejandro Garnacho.
Erling Haaland could become the first player in Premier League history to score three consecutive hattricks, as Manchester City face Brentford.
Southampton clinched promotion back to the Premier League after a one-year exile as Adam Armstrong sealed a 1-0 win against Leeds in the Championship play-off final on Sunday.
Leicester City moved four points clear of Leeds United with both sides having two matches remaining.
Jeremy Sarmiento proved to be a 'super sub' after scoring a stoppage-time winner as Ipswich returned to the top of the Championship on Monday with a dramatic 3-2 win at home to Southampton.
Chelsea have signed Romeo Lavia on a seven-year contract from Southampton after the teenage midfielder rejected a move to Premier League rivals Liverpool.
Newcastle completed the signing of defender Tino Livramento from Southampton on Tuesday for a reported initial fee of 32 million pounds
Ghana centre-back Mohammed Salisu has joined Monaco on a five-year deal from Southampton