José Mourinho picked up his first Champions League win with his new club Benfica as Samuel Dahl's early goal set the stage for a 2-0 win over troubled Ajax.
Harvey Barnes scored twice after coming off the bench to help Newcastle inflict more Champions League pain on Jose Mourinho's Benfica with a 3-0 win.
Elsewhere in the second round of matches in the league phase of Europe's elite club competition, Tottenham battled back to draw with Bodo/Glimt as Bayern Munich, Atletico Madrid, Marseille and Inter Milan recorded big wins.
Jose Mourinho began his second spell in charge of Benfica with a comfortable 3-0 win at AVS on Saturday.
Benfica sacked coach Bruno Lage following Tuesday's Champions League defeat to minnows Qarabag, the club announced, with some media claiming that Jose Mourinho is in line to take over.
Chelsea beat Benfica in a game which went on for close to five hours at the Club World Cup on Saturday to set up a quarter-final showdown with Brazilian side Palmeiras.
The ongoing FIFA Club World Cup has entered the Round of 16 stage. The group stage is over while the next round will be starting on Saturday.
Benfica beat Bayern Munich 1-0 in searing heat at the Club World Cup on Tuesday to progress to the last 16 as group winners.
Lamine Yamal and Raphinha dazzled as Barcelona thumped Benfica 3-1 on Tuesday, reaching the Champions League quarter-finals 4-1 on aggregate.
Barcelona vs Benfica LIVE Streaming, UEFA Champions League: Barcelona have a small 1-0 lead heading into the second leg match.
Raphinha claimed Barcelona a 1-0 Champions League last-16 first leg win at Benfica on Wednesday, despite the Catalan giants playing most of the game with 10 men.
Barcelona vs Benfica Live Streaming, Champions League Live Telecast: Barcelona look to continue their solid run in the Champions League as they take on Benfica in the Round of 16 1st Leg encounter in Lisbon.
Barcelona face Benfica on Wednesday in a Champions League last 16 first leg clash with their status as one of Europe's elite sides restored, midfielder Pedri Gonzalez playing a key role in their revival.
Vangelis Pavlidis scored his sixth goal in this season's Champions League to give Benfica a 1-0 win away to 10-man Monaco in the first leg of their knockout phase play-off tie on Wednesday
Barcelona completed a stunning comeback from 2-4 down to win 5-4 against Benfica, courtesy of a Raphinha 96th minute winner.
The win ensured direct qualification to the UEFA Champions League Round of 16 to Barcelona.
Despite the win, Bayern Munich still have work to do in Europe, with this season's Champions League final on home soil.
Atletico have now won just one of their last 10 Champions League away matches.