Paris Saint-Germain lost 1-0 at Nice in Ligue 1 on Saturday ahead of next week's trip to Real Madrid in the second leg of their blockbuster Champions League last-16 tie
Lionel Messi produced a fine performance in the first half against Lyon but was subbed off by PSG manager Mauricio Pochettino 14 minutes from time.
Ligue 1: Mauricio Pochettino celebrated his first victory as Paris Saint-Germain coach on his home debut on Saturday as Moise Kean set the reigning champions on their way to a 3-0 win over Brest.
Kylian Mbappe's last-minute defection is a significant blow for PSG with Neymar and Mauro Icardi already ruled out of Wednesday's Champions League game in Germany.
Champions League: Paris Saint-Germain will go into their match against Manchester United on October 20 without Argentinian striker Mauro Icardi.
Paris Saint-Germain are likely to be without seven of their first team players as they tested positive for coronavirus ahead of the start of the new season.
PSG are due to play their first game of the new Ligue 1 season away at Lens on September 10, but there are increasing doubts as to whether that match will now go ahead.
Paris Saint-Germain have signed Argentina international Mauro Icardi from Inter Milan on a four-year deal.
Mauro Icardi hammered home a magnificent volley in the 86th minute to draw Inter level while Matias Vecino scored a dramatic injury-time winner.
Two-time champions Argentina reached the final in Brazil in 2014, losing to Germany 1-0 after extra time.