Joao Felix was sent off and Antoine Griezmann failed to fire again as Atletico Madrid were held to a goalless draw by Athletic Bilbao on Saturday.
James Rodriguez came on for the last half-hour after labouring in training with a calf strain but could not pull Colombia level after Yuya Osako's goal.
Radamel Falcao was caught in a sandwich between goalkeeper Yoann Cardinale and defender Paul Baysse just before half-time in Monaco's 0-4 defeat to Nice in French Ligue 1
The 29-year-old scored only four times last season for Manchester United and this year he has netted only once for the 'Blues'. The Colombian forward was not even named on the bench for the 2-0 victory over Aston Villa on Saturday.
Radamel Falcao endured a frustrating season at Manchester United in 2014-15
Radamel Falcao failed to find his feet on loan at Manchester United last season, but Javier Mascherano insists that the 29-year-old will regain his form that he showed before bowing out with a serious knee injury sustained in early 2014.
Chelsea, the English Premier League champions, are closing in on an agreement to take Radamel Falcao on loan next season. Falcao endured a difficult spell on loan at Manchester United last season scoring just four goals in 29 appearances.
Radamel Falcao spent last season on loan at Manchester United but could only manage four goals in 29 appearances for the Old Trafford club.
Manchester United have sent Radamel Falcao back to Monaco with many saying his form has spiraled. Falcao though insists he is more of a complete player now than he ever was in the past.
In the early hours of Friday morning, the oldest international football tournament in the world will kick off when hosts Chile take on Ecuador in the opening match of the 2015 Copa America.