James Rodriguez came on for the last half-hour after labouring in training with a calf strain but could not pull Colombia level after Yuya Osako's goal.
Radamel Falcao was caught in a sandwich between goalkeeper Yoann Cardinale and defender Paul Baysse just before half-time in Monaco's 0-4 defeat to Nice in French Ligue 1
The 29-year-old scored only four times last season for Manchester United and this year he has netted only once for the 'Blues'. The Colombian forward was not even named on the bench for the 2-0 victory over Aston Villa on Saturday.
Radamel Falcao endured a frustrating season at Manchester United in 2014-15
Radamel Falcao failed to find his feet on loan at Manchester United last season, but Javier Mascherano insists that the 29-year-old will regain his form that he showed before bowing out with a serious knee injury sustained in early 2014.
Chelsea, the English Premier League champions, are closing in on an agreement to take Radamel Falcao on loan next season. Falcao endured a difficult spell on loan at Manchester United last season scoring just four goals in 29 appearances.
Radamel Falcao spent last season on loan at Manchester United but could only manage four goals in 29 appearances for the Old Trafford club.
Manchester United have sent Radamel Falcao back to Monaco with many saying his form has spiraled. Falcao though insists he is more of a complete player now than he ever was in the past.
In the early hours of Friday morning, the oldest international football tournament in the world will kick off when hosts Chile take on Ecuador in the opening match of the 2015 Copa America.
Uruguay are the reigning Copa America champions, having lifted the trophy after a 3-0 victory over Paraguay in the 2011 final in Buenos Aires. Uruguay have 16 titles, Argentina are next with 14 followed by Brazil with eight.
Colombia, fourth in the FIFA rankings behind Germany, Argentina and Belgium, are in Group C with Venezuela, Brazil and Peru.
Radamel Falcao has endured a poor season at United, having scored just four goals in 27 appearances.
Radamel Falcao hasn't started for United since late February, has just four club goals all season and seems almost certain to be sent packing when his season-long loan from Monaco expires at the end of the current campaign.
Radamel Falcao scored in Colombia's 3-1 win over Kuwait, taking his tally on par with Arnoldo Iguaran with 24 goals.
Falcao has been in a slump and has scored just four goals for Louis van Gaal's Manchester United side this season.
Falcao was an unused substitute in Manchester United's FA Cup quarter-final defeat at home to Arsenal on Monday and then was given a 72-minute run-out in the match at Old Trafford.
Falcao has just four goals in 19 appearances and was substituted in United's last match the FA Cup fifth round clash with Preston.
After Radamel Falcao's cousins told him about the case of Colombian John Andres Uyaban, the player immediately posted a message on Facebook. Ten days later, the family learned that the teen would receive the heart of another youth who had died in an accident.