Philippe Coutinho scored the first and Arturo Vidal the last but in between the game belonged to Luis Suarez.
Lionel Messi scored a hat-trick as Barcelona put four goals past PSV Eindhoven in the Champions League.
Suarez called Pogba an elite player who has won everything and Barcelona would be happy to have him.
A magical Lionel Messi and on-form Luis Suarez scored doubles apiece as champions Barcelona thrashed newly-promoted Huesca 8-2 to join Real Madrid at the top of La Liga on Sunday.
The Paris Saint-Germain striker was forced out of play after an injury in the round-of-16 match.
Uruguay and France are pitted in possibly one of the closest clashes in the quarter-finals.
The mouth-watering last-eight tie in Nizhny Novgorod is likely to be decided by a battle between Uruguay's stifling backline and the speed of Mbappe.
Luis Suarez said he had faith in the defence, which has conceded just one goal in World Cup 2018 so far, to nullify the threat from Kylian Mbappe.
Pepe's goal was the first time the South Americans' defence had been breached in the tournament.
FIFA World Cup 2018, Uruguay vs Portugal highlights straight fromFisht Stadium, Sochi
Cristiano Ronaldo will be sorely tested by old foe Diego Godin when Uruguay and Portugal clash.
Uruguay won all three of their group matches, beating hosts Russia 3-0 in their last outing, and are the only team yet to concede a goal at the tournament.
A draw would also be good enough to give Russia first place, thanks to the eight goals scored in two matches they have played.
The South Americans take on the hosts in their final Group A match on June 25 with top spot on the line, while Egypt and Saudi Arabia have been eliminated after both suffered back-to-back defeats.
FIFA World Cup 2018, Highlights, Uruguay vs Saudi Arabia: Uruguay beat Saudi Arabia 1-0 in their Group A match
Uruguay would be keen to add three more points when they meet under-fire Saudi Arabia in a World Cup 2018 Group A match.
Luis Suarez will be hoping for a successful 100th international game when Uruguay take on Saudi Arabia in a World Cup Group A match.