Belgium midfielder Marouane Fellaini, Portugal right-back Diogo Dalot, Scotland's Scott McTominay and Chile forward Alexis Sanchez all returned from international duty carrying knocks.
Neymar has grabbed the spotlight in Russia not for his goal-scoring abilities but for his theatrics.
Belgium coach Roberto Martinez said his side should accept they will be the underdogs in their World Cup quarter-final against star-studded Brazil on Friday.
Marouane Fellaini's new contract has the option to extend for a further 12 months after the two years have expired
Manchester United have now sealed their place in the Champions League next season and moved closer to their target of finishing at least second best to champions Manchester City.
Jose Mourinho threw on Juan Mata and Marouane Fellaini in the 63rd minute but bizarrely took Fellaini off just seven minutes later.
Fellaini added a late second from Jesse Lingard's cross-shot to send Jose Mourinho's side back to the top of the table after Huddersfield Town briefly overtook them by drawing with Southampton earlier in the day.
Booked for tripping Aguero in the 84th minute, Fellaini fouled him again seconds later and then blatantly butted the Argentinian, leaving referee Martin Atkinson no option but to send the Belgian off.
Kevin Pietersen, a Chelsea FC fan, was present at Stamford Bridge as the Premier League leaders took on Manchester United in the FA Cup quarterfinal.
Defending champions Manchester United advanced to the fifth round of FA Cup after defeating Wigan Athletic 4-0.
Bastian Schweinsteiger has declared he will not join another European club and Jose Mourinho suggested that if he stays, he may not even play in the Europa League or the English Football League Cup
Manchester United midfielder Marouane Fellaini will end the Premier League season as he started it -- serving a suspension
Marouane Fellaini revealed that Louis van Gaal, who is strict about time and discipline, got angry at the group of 10 players who got late for lunch and fined them on the spot.
Manchester United F.C. hit back through Ashley Young, Marouane Fellaini, Juan Mata and Chris Smalling to register a sixth successive league win after Sergio Aguero gave Manchester City F.C. an eighth-minute lead at a blustery Old Trafford.
Manchester United take on Aston Villa on Saturday with the hope to strengthen their chances to finish in the top four and be eligible for Champions League football next season.
Manchester United manager Louis van Gaal has put Fellaini's absence from the squad down to a mystery 'virus', revealing after Friday's win at home to Newcastle that the giant midfielder would not figure against Tottenham on Sunday.
Belgium international Marouane Fellaini, who followed manager David Moyes from Everton to Old Trafford last year, failed to impress as Manchester United slipped to a disappointing seventh-place finish in the Premier League in the 2013-14 season.
The incident is believed to have taken place when Marouane Fellaini and Sergio Aguero tussled in the first half of Manchester City's 1-0 victory.